DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Limch1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_036021493.1	Gene:	Limch1 / 77569	MGIID:	1924819	Length:	1511	Species:	Mus musculus

Alignment Length:	943	Identity:	173/943 - (18%)
Similarity:	293/943 - (31%)	Gaps:	349/943 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VSPNS-CVETP--------KAPEWLSK-LESRREQL-------KRSKL--------GHEAGAGA- 42
            :||.| |...|        ||| ||:. |||:.||:       |..::        |.|.....
Mouse   683 LSPQSDCRTVPSGTDGRLKKAP-WLAPVLESQEEQVCIQSNNPKTEEVTPTQLPQDGREQNEEVI 746

  Fly    43 -------PCAECKDKCPGLDLHFWRKVCRNCKCPKIQHVCPDDDDATGWAQFE--------ILGQ 92
                   |..:..::|.|               |......|..|||...:.|:        :|..
Mouse   747 QKEHEMLPRVQRPEECSG---------------PLYGPRTPVSDDAESTSMFDMRCEEEAAVLPH 796

  Fly    93 IRAKPAYIKIKALASQPVQLEWVPP---------NAAPDVV-----TDYMEKLGTAQIPVAGSDA 143
            .||:...:::.....:....:|...         :|:.|::     ...||||      ::|.|.
Mouse   797 SRARQEQLQLINNQLREEDDKWQDDLARWKSRRRSASQDLIKKEEERKKMEKL------MSGEDG 855

  Fly   144 ALKRKMQL--------ELQVPPHDLDAALCDGLTETEAIQ-LQQYVQKLREQCVGQGVVVRLG-- 197
            ..:|:..:        |.:....:|..|..:..::.||.. ||||:::.   .:.:.|:.||.
Mouse   856 TSERRKSIKTYREIVQEKERRERELHEAYKNARSQEEAEGILQQYIERF---TISEAVLERLEMP 917

  Fly   198 ---DRLNHAQVEHVA-----PALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASA 254
               :| :|:...:|:     |:  |.:..:|  |||. .|....|:...:|...|.:::||..:.
Mouse   918 KILER-SHSTEPNVSSFPNDPS--PMKYLRQ--QSLP-PPKFTATVETTIARTSVPESIASAGTG 976

  Fly   255 HP-KLLVAFSEPLCESTAQFEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLN 318
            .| |::...:.|:...          |..::.|   .|:..|.:....|               .
Mouse   977 SPSKIITPNTVPMLTP----------RPYSQPK---NSQEVLKTFKVDG---------------K 1013

  Fly   319 ISRDPKLGPIAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPG--TPFNSPLPLK---NPVQIR 378
            :|.:.::.|..|..|| ...|...|      |.|.:|..:...|  |..:||:.:|   |.::|.
Mouse  1014 VSMNGEMAPGDEEGKE-KEGPAAAA------PGPSLTKSQMFEGVATVHDSPVQVKQGSNSIEIN 1071

  Fly   379 M-------------------GAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRDPVFAQILQA 424
            :                   ..|..:|...|                |...|.:.|       .|
Mouse  1072 IKKPNSAPQELTAASEETESNGQEDEDGEER----------------PGTGDLEPD-------SA 1113

  Fly   425 EPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNP----ATRAQL---QSVGLDKNMLQSA 482
            ||........|.....:.|..|:.|.....:.|.....|    :.:.:|   |.|...|:....|
Mouse  1114 EPQHFTTTVTRCSPTVALVEFSSNPQLKNEVPEQGQKKPEDEMSGKVELVLSQKVAKPKSPEPEA 1178

  Fly   483 VSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQV----------------------------HDWL 519
            ....|:.|::..:        :|.||..|..|.                            ..|.
Mouse  1179 TLTFPFLDKMPET--------NQLHLPNPSSQADSPSSEKSPGSTPFKFWAWDPEEERRRQEKWQ 1235

  Fly   520 LDDDQLLD-----EIDKVFADMANGCKDI----------------------SYPKPSLGELPTSQ 557
            .:.::||.     |.||:..:.....|::                      :....|..:|.||.
Mouse  1236 QEQERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTISSSSADQLSTSL 1300

  Fly   558 S--SDSGFHSK--------------PPTPGYGSEDLTAGQGRFASIPGIEDMNMYPSCAGMPEQF 606
            |  ..||..:|              ..||...::..:..:.|...:|  |:.::.||.:..||..
Mouse  1301 SVTEGSGTRNKMDLENCPDKENERRQKTPFQENDGDSLLKTREGGLP--EEQSLTPSPSANPEIS 1363

  Fly   607 QQLRLHGD-----EAS----GKN------------------ST------------RTI------- 625
            ....:|.|     ||.    |.|                  ||            :||
Mouse  1364 VSKGIHQDPQLEAEAGAPHCGTNPQPAQDPPRNQQIPNPPTSTSEDVKPKTLALEKTINHQMESP 1428

  Fly   626 -----------LCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVF 679
                       ||:.|...:..|...:...   ..:.:|..||:|..|:..|.|.|
Mouse  1429 GERRKSISGKKLCSSCGLTLGKGAAMIIET---LNLYFHIQCFRCGICKGQLGDAV--------- 1481

  Fly   680 CGRDLAIRLKIPRCRACDELIFTKEYTAAEEAT 712
            .|.|:.||..:..|..|    :.:..:|.:..|
Mouse  1482 SGTDVRIRNGLLNCTDC----YMRSRSAGQPTT 1510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	21/109 (19%)
		LIM1_Testin_like	627..684	CDD:188726	12/56 (21%)
		LIM2_Testin_like	691..748	CDD:188727	4/22 (18%)
		LIM	755..810	CDD:295319
Limch1	XP_036021493.1	CH_LIMCH1	23..140	CDD:409127
		DUF4757	250..>311	CDD:406382
		DUF4757	<739..872	CDD:406382	23/153 (15%)
		GBP_C	<1225..1262	CDD:419202	6/36 (17%)
		LIM	1441..1498	CDD:214528	16/68 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900