DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tes and ZNF185

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_016885310.1	Gene:	ZNF185 / 7739	HGNCID:	12976	Length:	766	Species:	Homo sapiens

Alignment Length:	696	Identity:	149/696 - (21%)
Similarity:	231/696 - (33%)	Gaps:	228/696 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PKIQHVCPDDDDATGWAQFEILGQIRAKPAYIKIKALASQP---------------VQLEWVPPN 118
            |.:....|..:.|.|       |:.:|..| |.|:.|.|.|               |:|:.:.|.
Human   236 PALARSTPGSNSADG-------GRTKASRA-IWIECLPSMPSPAGSQELSSRGEEIVRLQILTPR 292

  Fly   119 A-----APDVVTDYMEKLGTAQIPVAGS---DAALKRKMQLEL------QVPPHDL---DAALCD 166
            |     ||||.       |....|  |:   :|...|::|.:|      :.|..|.   .|.|.|
Human   293 AGLRLVAPDVE-------GMRSSP--GNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSD 348

  Fly   167 GL-------TETEAIQLQQYVQKLREQCVGQGVVVRLGDRLNH---AQVEHVAPALMPTQEAQQT 221
            |.       :..|.:.......:....|........|.|:..|   :|.....||.:.:...
Human   349 GNVGSGATGSRPEGLAAVDIGSERGRLCAAASFASFLEDQDGHSANSQSCKPRPAAISSSAT--- 410

  Fly   222 WQSLGLMPVADDTLNELLANPKVAQALASPASAHPKLLVAFSEPLCEST----AQFEENGALRAQ 282
              |:..:| ||...|        :.|....|.|.||..:|..|....:|    |..|..||.|..
Human   411 --SVSAVP-ADRKSN--------STAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGG 464

  Fly   283 TREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGPIAEFRKEYVNNPQFRAEINT 347
            ..:..:...:||..|              ..|::.:.|...:|     .|:|...:.:
Human   465 QGDPAVPAQQPADPS--------------TPERQSSPSGSEQL-----VRRESCGSRR------- 503

  Fly   348 ICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDC----GLPA 408
             .|||..:|.|.|       |||...|.|   |:       :||.|.||   .:.||    |...
Human   504 -VPQPDSSPKKIP-------PLPCGGPGQ---GS-------IRRDKAGG---HIGDCLLTPGASV 547

  Fly   409 NTDYDRDPVFAQILQAEPLKHAFQE----ARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQL 469
            .||::...|      |..:..|:|:    .|.|:...:|.... ||           :|:|..|
Human   548 LTDFEGKDV------ATKVGEAWQDRPGAPRGGQGDPAVPTQQ-PA-----------DPSTPEQ- 593

  Fly   470 QSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPM----KQVHDWLLDDDQLLDEID 530
                      |::.|.:..:.|. .|...:..|...|.:...:    :|.|.::......||.
Human   594 ----------QNSPSGSEQFVRR-ESCTSRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDS-- 645

  Fly   531 KVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIED--- 592
                  ::..|.|.:.|    |...:....||   ||.:            .|::::..|||
Human   646 ------SSTTKGILFVK----EYVNASEVSSG---KPVS------------ARYSNVSSIEDSFA 685

  Fly   593 MNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPGCF 657
            |...|.|...|        :.:..:|.      :|..||:.| .....:..:..|  |..|..||
Human   686 MEKKPPCGSTP--------YSERTTGG------ICTYCNREI-RDCPKITLEHLG--ICCHEYCF 733

  Fly   658 KCITCRELLADLV--YFFHQGQVFCGRDLAIRLKIPRCRACDELIF 701
            ||..|.:.:.||:  .|.|:..:.||:             |.|.:|
Human   734 KCGICSKPMGDLLDQIFIHRDTIHCGK-------------CYEKLF 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	23/110 (21%)
		LIM1_Testin_like	627..684	CDD:188726	18/58 (31%)
		LIM2_Testin_like	691..748	CDD:188727	3/11 (27%)
		LIM	755..810	CDD:295319
ZNF185	XP_016885310.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900