DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Scel

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_075024.2	Gene:	Scel / 64929	MGIID:	1891228	Length:	652	Species:	Mus musculus

Alignment Length:	629	Identity:	116/629 - (18%)
Similarity:	187/629 - (29%)	Gaps:	240/629 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 PALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASAHPKL------LVAFSEPL-- 266
            ||..|.::.:|:|     .|......|   |:|..|.:...|| .||.|      .:|..:||
Mouse   126 PATTPVKKKRQSW-----FPPPPPGHN---ASPSTAASRRDPA-LHPPLPPKPCSPIASPKPLGR 181

  Fly   267 ------------CESTAQFEE-------------------------------------------N 276
                        |..|.:..|                                           :
Mouse   182 TNRQIHAATAGACGETERHAERNIRTEDLDDIIRVAAALQKTDKGEELDNLIRMNKSLNRNQGLD 246

  Fly   277 GALRAQTREKLLGISKPALLSLVTHGIVYDK------VLGILQEKKLNISRDPKLGPIAEFRKEY 335
            |..||..:.:.|.....:|.||:......|:      ..|.|  ||:|...||..
Mouse   247 GLFRANLKAQQLDKRAQSLESLIYMNTQTDRDGKGNQAFGSL--KKINQRADPDR---------- 299

  Fly   336 VNNPQFRAEINTIC--------PQPPMTPIKSPPGTPFNSP--LPLKNPVQIRMGAQMRQDTP-M 389
             .:...|:.|.|..        .|.....||..|.|..|..  ..|.|.:::         || :
Mouse   300 -RSQDLRSVIRTHATAERIGRRKQDLDGLIKVNPDTNKNMKRGKSLDNLIKV---------TPEV 354

  Fly   390 RRVKFGGVSTIVYDCGLPANTDYD-RDPVFAQILQAEP-----LKHAFQEARAGRAPSSVVISNI 448
            .|...||.|...:..|:||.:..: ||.....:::..|     .:|:..|          :|:..
Mouse   355 NRSNKGGPSLDNFTKGVPARSRANQRDQDLDSLIKVTPSANRSSQHSLDE----------LINTS 409

  Fly   449 PAPVASLAE---------------------------LRGLNPATRAQLQSVGLDKNMLQSAVSNA 486
            |..:.:.|.                           :||....||.: ||..|| |:::...|
Mouse   410 PQTIKTTARHQDLDKFIKVNPDVLTNNQRNHDVDSTIRGNPTGTRCE-QSEELD-NLIKVKPS-- 470

  Fly   487 PYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADMANGCKDISYPKPSLG 551
                    :|.:.....|    |:.:.:|:..:.:.:..:|       ..|||..:..:.:.:..
Mouse   471 --------ALRNTNGGQD----LESLTEVNSHVAEKNGRID-------GQANGLTNSLFKESTRA 516

  Fly   552 -----ELPTSQSSDSG-----------------FHSKPPTPGYGSEDLTAGQGRFASIPGIEDMN 594
                 |...|.||:||                 .:||.|..||..           :|.|.....
Mouse   517 SVYSYEARNSLSSNSGNKNGGPKDTVVYTRTYVENSKSPKDGYQE-----------NISGKYIQT 570

  Fly   595 MYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKC 659
            :|                  ..|.::.....:|..|.:|:.: |..:..|..  :|..|..||||
Mouse   571 VY------------------STSDRSVIERDMCTYCRKPLGV-ETKMILDEL--QICCHSTCFKC 614

  Fly   660 ITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTK 703
            ..|:..|.:|.         .|..:.|..:...|..|...:..|
Mouse   615 EICKRPLENLQ---------AGDSIWIYRQTIHCEPCYSKVMAK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	15/56 (27%)
		LIM2_Testin_like	691..748	CDD:188727	3/13 (23%)
		LIM	755..810	CDD:295319
Scel	NP_075024.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..180		17/62 (27%)
		15 X approximate tandem repeats	207..496		57/336 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..385		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..455		3/18 (17%)
		LIM	584..642	CDD:214528	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900