DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and PXN

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_016875215.1	Gene:	PXN / 5829	HGNCID:	9718	Length:	1135	Species:	Homo sapiens

Alignment Length:	886	Identity:	194/886 - (21%)
Similarity:	293/886 - (33%)	Gaps:	259/886 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PKAPEWLSKLESRREQLKRSKLGHEAGAGAPCAECKDKCPGLDLHFWRKVCRNCKCPKIQHVCPD 77
            |.||.||..                ||.|........:.|.::...|              ....
Human   349 PVAPSWLDL----------------AGLGVMPDTFNSRSPSVEGSLW--------------AVGT 383

  Fly    78 DDDATGWAQF-EILGQIRAKPAYIKIKALASQPVQLEWVP--PNAAPDVVTDYM----------E 129
            :.....|... .|..::...|....:....|..:|....|  |.|:|....:.:          |
Human   384 ESQGRDWRHLPTITSELSGAPRCHTVPCAGSTALQEPGEPQGPPASPSCPEEALAATWEQPWASE 448

  Fly   130 KLGTAQIPVAGSDAALKRKMQLELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVVV 194
            ..|..::|.:|  ||...:...|..|...|..|...|..|.||...|||  ::.|.:   .|
Human   449 VFGPERMPPSG--AARSFQEVTEPAVVAVDRQAIFPDTWTLTEEHGLQQ--ERPRPE---PG--- 503

  Fly   195 RLGDRLNHAQVEHVAPALMPTQE--AQQTWQSLGLMPVADDTLNELLANPK-VAQALASPASAHP 256
            |||..         :||.:.|::  |:.|.:.....|....   |...:|: ..:|........|
Human   504 RLGSS---------SPASVTTEQLGAKMTERGSVARPTQGP---ETPRSPEGTTEAATQDGKEQP 556

  Fly   257 KLLVAFSEPLCESTAQFEENGALRAQTREKL-LGISKPALLSLVTHGIVYDKVLGILQEKKLNIS 320
            :|..|.:.....:|.:...:|.:|:..|... .|.:.|                         :|
Human   557 ELPCAMAMGTPSTTERISTSGQIRSVIRRSWESGHAHP-------------------------MS 596

  Fly   321 RDPKLGPIAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQ 385
            |:|              :|:.|.:        |.|..::|      |...|...:|.|:|.|...
Human   597 REP--------------SPRRRLD--------PATLSRTP------SQEQLIAELQGRLGIQPEA 633

  Fly   386 DTPM---------------------RRVKFGG--VSTIVYDCGLPANTDYDRDPVFAQI-LQAEP 426
            :.|.                     |..:.||  |..:|:..|.|.       |:...| :.|.|
Human   634 EEPAEAAGPSAQDWLTEGVIITVQPRGKRAGGQLVEKVVFPPGSPI-------PLRRTISVLASP 691

  Fly   427 LKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPAT----RAQLQSVG---LDKNMLQSAVS 484
            .....|......|.||       :|:.||.....|.|:.    .:.:||.|   .|:.:...|:.
Human   692 SVPLLQHRTDAAASSS-------SPLPSLLASSPLGPSAYTCGSSGVQSAGEEPHDEGVQGPALP 749

  Fly   485 -NAPYYDRLFRSLHDKGISHDQCHLLQPMKQVH-------------------------------- 516
             .||:      ::...|...|:..|..|| |:.
Human   750 IPAPH------TMRSVGCQTDEDPLFPPM-QIQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGG 807

  Fly   517 -DWLLDDDQLLDEIDKVFADMANGCKDISYPKPSLG--ELPTSQSSDSGFHSKPPTPGYGSEDLT 578
             .|.|::..||..|.   :.:..|.|   ||.|...  ..|:.:|.|    ..||.|.:    :.
Human   808 GSWPLEEVVLLVSIS---SSVQEGEK---YPHPCAARHRTPSLRSPD----QPPPCPQF----MA 858

  Fly   579 AGQGRFASIPGIEDMNMYPSCAGMPEQFQQL-----RLHGDEASGKNSTRTI---LCADCNQPIA 635
            .|:...:|.||           |.|:...||     .|..|  ..|....|:   :|..|.:|||
Human   859 QGKTGSSSPPG-----------GPPKPGSQLDSMLGSLQSD--LNKLGVATVAKGVCGACKKPIA 910

  Fly   636 MGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELI 700
             |:|..   ..||  .|||..|.|..|:|.:....:|...||.:|.:|.. .|..|||..|:..|
Human   911 -GQVVT---AMGK--TWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYH-NLFSPRCYYCNGPI 968

  Fly   701 FTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPA 765
            ..|..||.:. |:|.:||.|.||......:.:  .||.....|...|..:||.:|..|..||  .
Human   969 LDKVVTALDR-TWHPEHFFCAQCGAFFGPEGF--HEKDGKAYCRKDYFDMFAPKCGGCARAI--L 1028

  Fly   766 DQGVAWGDVHWHASCFVCAGVQCSKPLIGGRFCVKENMPFC 806
            :..::..:..||..||||.  :|..|.:.|.|...:..|:|
Human  1029 ENYISALNTLWHPECFVCR--ECFTPFVNGSFFEHDGQPYC 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	25/98 (26%)
		LIM1_Testin_like	627..684	CDD:188726	20/56 (36%)
		LIM2_Testin_like	691..748	CDD:188727	18/56 (32%)
		LIM	755..810	CDD:295319	16/52 (31%)
PXN	XP_016875215.1	Paxillin	60..259	CDD:281527
		LIM1_Paxillin_like	902..954	CDD:259830	21/57 (37%)
		LIM2_Paxillin	961..1012	CDD:188791	16/53 (30%)
		LIM3_Paxillin_like	1020..1072	CDD:188724	16/52 (31%)
		LIM4_Paxillin	1079..1130	CDD:188795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910