DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and pxnb

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_021334029.1	Gene:	pxnb / 565130	ZFINID:	ZDB-GENE-130530-697	Length:	1197	Species:	Danio rerio

Alignment Length:	915	Identity:	175/915 - (19%)
Similarity:	286/915 - (31%)	Gaps:	345/915 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAVSPNSCVETPKAPEWLSKLESRREQLKRSKLGHEAGAGAPCAECKDKCPGLDLHFWRKVCRN 65
            :::.|||:...:|::...:|::..|...|.           .|.:        :||:..|
Zfish   451 LNSYSPNTKSPSPRSSPAISRVNERVSPLM-----------TPAS--------IDLYLSR----- 491

  Fly    66 CKCPKIQHVCPDDDDATGWAQFEILGQIRAKPAYIKIKALASQPVQLEWVPPNAAPDVVTDYMEK 130
               |:.:.:.|            :....|:....:...:..|.|..|.  ||...|...|
Zfish   492 ---PETKPLSP------------VPSLPRSPLPAVSESSFLSLPKALS--PPPIIPTSPT----- 534

  Fly   131 LGTAQIPVAGSDAA-LKRKMQLELQVPPHDLDAALCDGL-----------------TETEAIQLQ 177
            ||.::.|....::| |:..:.|:..:.|...:.:|.|.|                 |.:.:.||.
Zfish   535 LGVSKSPSPKQESAYLEPVVSLKPHLEPPTYEPSLDDALDKLLAMSFSRPENETHITASASSQLT 599

  Fly   178 QYVQ-KLREQCV------------------GQGVVVRLGD---RLNHAQVE----HVAP--ALMP 214
            ...| ::.|:.:                  |.|::....|   .|:.|.:|    :..|  ::.|
Zfish   600 SEAQPEIYEESIVAADRSDIHPDTHTESEMGDGLLEDQSDCRSDLDWADMELKMAYEGPDGSMTP 664

  Fly   215 TQEAQQTWQSLGLMPVA-DDTLNELLANPKVAQALAS---PASAHPKLLVAFSEPLCESTAQFEE 275
            ..||  :|....|.|.: ..|.:..:..|.:..|...   .||.|.|.::..::.: ::......
Zfish   665 MTEA--SWMDDSLTPSSCPGTPDAQMDLPMLHMAGTMDRISASGHIKSVIRRTKEI-QNVHPMYR 726

  Fly   276 NGALR----------AQTREKL-------LGISKPALL------SLVTHGIV------------- 304
            :|.:|          :.::::|       |||::....      ..:|.|::
Zfish   727 DGLIRRKMGPLIFHKSNSQDRLIEELQGKLGIARKEKAKKQQPDDWLTEGVIVMSNPKRSREDHN 791

  Fly   305 --YDKVL----GILQEKKLNI-------------SRDPKLGPIAEFRKEYVNNPQFRAEINTICP 350
              .||::    ..|.::|:.:             :.:||..|:.:....            .:.|
Zfish   792 RDVDKIIIPPESPLPQRKMILPPQSPPMPRPPPPAEEPKCPPVVKLAPA------------PLPP 844

  Fly   351 QPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRD 415
            .||..| ..||..|...|.|...||      ..:..||                          :
Zfish   845 PPPPAP-SPPPREPTPPPQPTLPPV------PPKPPTP--------------------------E 876

  Fly   416 PVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQSVGLDKNMLQ 480
            ||.......:|        :....||.:   ..||||:.        |..   |.|||....
Zfish   877 PVVVPAPSPKP--------KPAPPPSPI---PPPAPVSP--------PKV---LASVGCQTE--- 916

  Fly   481 SAVSNAPYYDRLFRSL----HDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADMANGCK 541
                    ||.||..|    ..|| .|.|.:.|..|
Zfish   917 --------YDPLFPPLQIMAQGKG-PHGQANKLDNM----------------------------- 943

  Fly   542 DISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIEDMNMYPSCAGMPEQF 606
                    ||.|      .|..|.      .|.:.:..|
Zfish   944 --------LGSL------QSDLHK------LGVQTVAKG-------------------------- 962

  Fly   607 QQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVY 671
                               :|..|::|| :|:|.....|     .|||..|.|..|:|.:....:
Zfish   963 -------------------VCGACSKPI-VGQVVTAMGR-----TWHPEHFVCTHCQEEIGSRNF 1002

  Fly   672 FFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIADE 736
            |..:||.:|.||.. .|..|||..|:..|..|..||.:. |:|.:||.|.||......:.:  .|
Zfish  1003 FEREGQPYCERDYH-HLFSPRCYYCNGPILDKVVTALDR-TWHPEHFFCAQCGAFFGPEGF--HE 1063

  Fly   737 KSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHASCFVCAGVQCSKPLIGGRFCVKE 801
            |.....|...|..|||.:|..|..||  .:..::.....||..||||.  :|..|.:.|.|...:
Zfish  1064 KDGKAYCRKDYFDLFAPKCGGCARAI--LENYISALSSLWHPECFVCR--ECFTPFVNGSFFEHD 1124

  Fly   802 NMPFC 806
            ..|:|
Zfish  1125 GQPYC 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	22/123 (18%)
		LIM1_Testin_like	627..684	CDD:188726	19/56 (34%)
		LIM2_Testin_like	691..748	CDD:188727	18/56 (32%)
		LIM	755..810	CDD:295319	16/52 (31%)
pxnb	XP_021334029.1	Paxillin	96..272	CDD:308898
		Atrophin-1	<178..684	CDD:331285	49/280 (18%)
		LIM1_Paxillin_like	964..1016	CDD:259830	20/57 (35%)
		LIM2_Paxillin_like	1023..1074	CDD:188723	16/53 (30%)
		LIM3_Paxillin_like	1082..1134	CDD:188724	16/52 (31%)
		LIM4_Paxillin	1141..1192	CDD:188795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910