DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and LIMS2

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_060450.2	Gene:	LIMS2 / 55679	HGNCID:	16084	Length:	365	Species:	Homo sapiens

Alignment Length:	283	Identity:	79/283 - (27%)
Similarity:	112/283 - (39%)	Gaps:	44/283 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 LGELPTSQSSDSGFHSKPPTPGYGS-EDLTAG------QGRFASIPGIEDMN--MYPS----CAG 601
            ||.|..|.......|.:.|.|..|: .|..|.      |.||:....|.:.|  :|..    ||.
Human     5 LGALAASGLYRRRQHRQSPPPATGNMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQ 69

  Fly   602 MPEQFQQLRLHGDEASGKNSTR-------TILCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKC 659
            ....|.:...:  |..|:....       ...|..|.:.| :|.| :||....    ||||||:|
Human    70 CFRPFPEGLFY--EFEGRKYCEHDFQMLFAPCCGSCGEFI-IGRV-IKAMNNN----WHPGCFRC 126

  Fly   660 ITCRELLADLVYFFHQGQVFC----GRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCC 720
            ..|...||||.:..:.|:..|    .|:.|..|....|:.| .|:..::........:|..||.|
Human   127 ELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRC-HLVIDEQPLMFRSDAYHPDHFNC 190

  Fly   721 YQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGV--AWGDVHWHASCFVC 783
            ..|.:.|..:   |.|......||.|:|::....|..|:   .|.:..|  |.|. .||...|||
Human   191 THCGKELTAE---ARELKGELYCLPCHDKMGVPICGACR---RPIEGRVVNALGK-QWHVEHFVC 248

  Fly   784 AGVQCSKPLIGGRFCVKENMPFC 806
            |  :|.||.:|.|...|:.:.:|
Human   249 A--KCEKPFLGHRHYEKKGLAYC 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	22/60 (37%)
		LIM2_Testin_like	691..748	CDD:188727	14/56 (25%)
		LIM	755..810	CDD:295319	19/54 (35%)
LIMS2	NP_060450.2	LIM1_PINCH	39..97	CDD:188717	11/59 (19%)
		LIM2_PINCH	100..151	CDD:188718	21/56 (38%)
		LIM3_PINCH	164..214	CDD:188719	13/53 (25%)
		LIM4_PINCH	220..273	CDD:188720	19/56 (34%)
		LIM5_PINCH	281..334	CDD:188721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810