DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tes and FBLIM1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001019386.1	Gene:	FBLIM1 / 54751	HGNCID:	24686	Length:	374	Species:	Homo sapiens

Alignment Length:	432	Identity:	84/432 - (19%)
Similarity:	141/432 - (32%)	Gaps:	141/432 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 PVFAQILQAEPLKHAFQEARAGR---APSSVV-----ISNIPAPVASLAELRGLNPATRAQLQSV 472
            |....:..||.::.|..|||.||   ||:.:.     ::..|:|..:........||...||.:.
Human    19 PPRRDVAVAEEVRQAVCEARRGRPWEAPAPMKTPEAGLAGRPSPWTTPGRAAATVPAAPMQLFNG 83

  Fly   473 GLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADMA 537
            |                                |....|       :||.:.:|.::|.:
Human    84 G--------------------------------CPPPPP-------VLDGEDVLPDLDLL----- 104

  Fly   538 NGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGY---GSEDLTAGQGRFASIPGIEDMNMYP-- 597
                    |.|                  ||.|..   ..|:..|..|. :.|..:|.:::.|
Human   105 --------PPP------------------PPPPPVLLPSEEEAPAPMGA-SLIADLEQLHLSPPP 142

  Fly   598 -----SCAGMPEQFQQLRLHGDEASG------KNSTRTILCADCNQPIAMGEVAVKADRAGKEIA 651
                 ...|...|...||...:|...      :....|.:||.|::.::..|:||:|.:.    .
Human   143 PPPQAPAEGPSVQPGPLRPMEEELPPPPAEPVEKGASTDICAFCHKTVSPRELAVEAMKR----Q 203

  Fly   652 WHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIK 716
            :|..||.|.|||..||...::...|:..|  :...:..:.||..|.|::......|..:| ||..
Human   204 YHAQCFTCRTCRRQLAGQSFYQKDGRPLC--EPCYQDTLERCGKCGEVVRDHIIRALGQA-FHPS 265

  Fly   717 HFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRC---------------KVAIGPAD 766
            .|.|..|...:..:.:....::.    :.|.|..:......|               ::::.|.
Human   266 CFTCVTCARCIGDESFALGSQNE----VYCLDDFYRYEKGLCTGWGAGTGRDPSRVKELSLSPG- 325

  Fly   767 QGVAWGDVHWHASCFVC-------AGV-----QCSKPLIGGR 796
               .|..|    ||.:.       ||:     .|:...:|||
Human   326 ---CWARV----SCLLVYYKEYYRAGLGAVAHACNPSTLGGR 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	18/56 (32%)
		LIM2_Testin_like	691..748	CDD:188727	12/56 (21%)
		LIM	755..810	CDD:295319	12/69 (17%)
FBLIM1	NP_001019386.1	Filamin-binding	1..70		13/50 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..119		21/147 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..176		6/40 (15%)
		LIM	183..236	CDD:259829	18/58 (31%)
		LIM2_FBLP-1	243..295	CDD:188758	12/56 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810