DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and POU3F4

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_000298.3	Gene:	POU3F4 / 5456	HGNCID:	9217	Length:	361	Species:	Homo sapiens

Alignment Length:	272	Identity:	57/272 - (20%)
Similarity:	82/272 - (30%)	Gaps:	93/272 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 DPKLGPIAEFRKEYV-------NNPQFRAEINTICPQPPMTPIKSPPGTPFN------------- 366
            |.:||.|...|..:|       |:|      |.....|...|..:..|.|.|
Human    87 DLQLGAIIHHRSPHVAHHSPHTNHP------NAWGASPAPNPSITSSGQPLNVYSQPGFTVSGML 145

  Fly   367 -----------------SPLPLKNPVQIRMGAQMRQD-----TP-------------MRRVKFGG 396
                             .|:..:.|....:|:...||     ||             .||:|.|.
Human   146 EHGGLTPPPAAASAQSLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGF 210

  Fly   397 VSTIVYDCGLPANTDYDRDPVFAQ--ILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELR 459
            ...   |.||...|.|..  ||:|  |.:.|.|:.:|:.                  :..|..|
Human   211 TQA---DVGLALGTLYGN--VFSQTTICRFEALQLSFKN------------------MCKLKPL- 251

  Fly   460 GLNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLL---QPMKQVHDWLLD 521
             ||........|.|...::.:.|........|....:..||:.  :.|.|   :|..|....|.|
Human   252 -LNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVL--ETHFLKCPKPAAQEISSLAD 313

  Fly   522 DDQLLDEIDKVF 533
            ..||..|:.:|:
Human   314 SLQLEKEVVRVW 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726
		LIM2_Testin_like	691..748	CDD:188727
		LIM	755..810	CDD:295319
POU3F4	NP_000298.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..131		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..192		7/47 (15%)
		POU	186..260	CDD:197673	22/98 (22%)
		Homeobox	281..335	CDD:365835	13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910