DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Tes

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001034433.1	Gene:	Tes / 500040	RGDID:	1566346	Length:	419	Species:	Rattus norvegicus

Alignment Length:	811	Identity:	174/811 - (21%)
Similarity:	242/811 - (29%)	Gaps:	422/811 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QLKRSKLGHEAGAGAPCAECKDKCPGLDLHFWRKVCRNCKCPKIQH---VCPDDDDATGWAQFE- 88
            ::|:..||||.|.||||.:||:.|.|.:||||||:||||||.:.:|   :..::|...| ..||
  Rat     6 KMKKMGLGHEQGFGAPCLKCKENCEGFELHFWRKICRNCKCGQEEHDVLLSTEEDRKVG-RLFED 69

  Fly    89 -----ILGQIRAK--PAYIKIKALASQP-----------VQLEWVPPNAAPDVVTDYMEKLGTAQ 135
                 ::.::::.  |.|.:...:.:.|           |..||.||.....:...||:.|...:
  Rat    70 TKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEK 134

  Fly   136 IPVAGSDAALKRKMQLELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVVVRLGDRL 200
            .|||||:.|..||.||..|:|.||.|.:.|..|:..|..:::|:|:|.:.:.:|.| .|:|...:
  Rat   135 QPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPKEVKEMEQFVKKYKSEALGVG-DVKLPSEM 198

  Fly   201 NHAQVEHVAPALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASAHPKLLVAFSEP 265
            |                                           ||.
  Rat   199 N-------------------------------------------AQG------------------ 202

  Fly   266 LCESTAQFEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGPIAE 330
                                                    |||
  Rat   203 ----------------------------------------DKV---------------------- 205

  Fly   331 FRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFG 395
                                       .:|.|
  Rat   206 ---------------------------HNPAG--------------------------------- 210

  Fly   396 GVSTIVYDCGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRG 460
                             ||                                |.||.|
  Rat   211 -----------------DR--------------------------------NTPAAV-------- 218

  Fly   461 LNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQL 525

  Rat   219 ----------------------------------------------------------------- 218

  Fly   526 LDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGI 590
                         |.||.|
  Rat   219 -------------GSKDKS---------------------------------------------- 224

  Fly   591 EDMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPG 655
                                     |..|.:..:..|  |...:..|:.|:.|:|||.:..|||.
  Rat   225 -------------------------AEAKKTQYSCYC--CKNTMREGDPAIYAERAGYDKLWHPA 262

  Fly   656 CFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCC 720
            ||.|.||.|||.|::||:..|:::|||......| |||..||||||:.|||.||...:|:|||||
  Rat   263 CFICSTCGELLVDMIYFWKNGKLYCGRHYCDSEK-PRCAGCDELIFSNEYTQAENQNWHLKHFCC 326

  Fly   721 YQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHAS--CFVC 783
            :.||..|||:.|:.  ..:.|:|..||.:..||.||.|..||.|..|.|.:.:..||||  ||:|
  Rat   327 FDCDNILAGKIYVM--VRDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLC 389

  Fly   784 AGVQCSKPLIGGRFCVKENMPFCSPTCVRSL 814
            :  .|||.|||.:|...|.|.|||..|.:.:
  Rat   390 S--CCSKCLIGQKFMPVEGMVFCSVECKKMM 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	32/86 (37%)
		LIM1_Testin_like	627..684	CDD:188726	26/56 (46%)
		LIM2_Testin_like	691..748	CDD:188727	29/56 (52%)
		LIM	755..810	CDD:295319	27/56 (48%)
Tes	NP_001034433.1	PET_testin	109..196	CDD:193604	27/86 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..164		10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222		0/22 (0%)
		LIM1_Testin	234..291	CDD:188797	3/56 (5%)
		LIM2_Testin	297..352	CDD:188800	2/54 (4%)
		LIM3_Testin	359..417	CDD:188803	2/57 (4%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352517
Domainoid	1	1.000	49	1.000	Domainoid score	I11468
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41051
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2617
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001604
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24211
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.000