DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Ldb3

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_006252699.3	Gene:	Ldb3 / 498587	RGDID:	1564875	Length:	771	Species:	Rattus norvegicus

Alignment Length:	737	Identity:	156/737 - (21%)
Similarity:	226/737 - (30%)	Gaps:	223/737 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VVTDYMEKLGTA---QIPVA-----GSDAALKRKM-----QLELQVPPHDLDAALCDGLTETEAI 174
            |.|.:||..|..   ..|||     |:..::..|:     |..|...|..|.:|      ||...
  Rat   196 VCTSHMEASGPVLPLGSPVAKASSEGTQGSVSPKVLPGPSQPRLYNNPIGLYSA------ETLRE 254

  Fly   175 QLQQYVQKLREQCVGQGVVVRLGDRL--NHAQVEHVAP---ALMPTQ-----EAQQTW------- 222
            ..|.|...||.:..|.|:   ||..|  ....|:..:|   |::.||     ||.: |
  Rat   255 MAQMYQMSLRGKASGAGL---LGGSLPVKDLAVDSASPVYQAVIKTQSKPEDEADE-WARRSSNL 315

  Fly   223 QSLGLMPVADDTLNELLANPKVAQALASPASAHPKLLVAFSEPLCESTAQFEENGALRAQTREKL 287
            ||.....:|..|..|.:.:|.                   .|.|..|:...|......:|....|
  Rat   316 QSRSFRILAQMTGTEYMQDPD-------------------EEALRRSSTPIEHAPVCTSQATSPL 361

  Fly   288 LGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGPIAEFRKEYVNNPQFRAEINTICPQP 352
            |..|.|:..:...                  |:..|.|...|...           .:......|
  Rat   362 LPASAPSPAAASP------------------IAASPTLATAAAAH-----------AVAASAAGP 397

  Fly   353 PMTPIKSP-PGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRDP 416
            ..:|:::| |.....||....:|..                              .|:|.|...|
  Rat   398 ASSPVENPRPQASAYSPAAATSPAP------------------------------AAHTSYSEGP 432

  Fly   417 --------------VFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPA-TR 466
                          :...:.|..|.........|..:|:....|..||...|.|.....:|| |.
  Rat   433 AAPAPKPRVVTTASIRPSVYQPVPASPYSPSPGANYSPTPYTPSPAPAYTPSPAPTYTPSPAPTY 497

  Fly   467 AQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDK 531
            :...:...       ..|.||.|:....:.:..|.|....   :|     .|:.|     |...:
  Rat   498 SPSPAPAY-------TPSPAPNYNPTPSAAYSGGPSESAS---RP-----PWVTD-----DSFSQ 542

  Fly   532 VFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIEDMNMY 596
            .||.               |:..||.|..:.....|.....|.:.....:|.|      :....:
  Rat   543 KFAP---------------GKSTTSVSKQTLPRGAPAYNPTGPQVTPLARGTF------QRAERF 586

  Fly   597 PSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPI------AMGEVAVKADRAGKEIAWHPG 655
            |:                      |:||.||..||..|      |||.            :|||.
  Rat   587 PA----------------------SSRTPLCGHCNNVIRGPFLVAMGR------------SWHPE 617

  Fly   656 CFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCC 720
            .|.|..|:..|||:.:...|..|:|.|... :...|.|..|:..|. .|...|...|:|...|.|
  Rat   618 EFNCAYCKTSLADVCFVEEQNNVYCERCYE-QFFAPICAKCNTKIM-GEVMHALRQTWHTTCFIC 680

  Fly   721 YQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGV-AWGDVHWHASCFVCA 784
            ..|.:|.....:..::  ..|.|...|..||:.:|..|...:...|:.: |.|.. ||.:||:||
  Rat   681 AACKKPFGNSLFHMED--GEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHT-WHDTCFICA 742

  Fly   785 GVQCSKPLIGGRFCVKENMPFC 806
              .|...|.|..|..|::.|.|
  Rat   743 --VCHVNLEGQPFYSKKDKPLC 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	23/86 (27%)
		LIM1_Testin_like	627..684	CDD:188726	20/62 (32%)
		LIM2_Testin_like	691..748	CDD:188727	14/56 (25%)
		LIM	755..810	CDD:295319	18/53 (34%)
Ldb3	XP_006252699.3	PDZ_signaling	50..126	CDD:238492
		DUF4749	240..341	CDD:406377	29/129 (22%)
		PHA03247	<426..576	CDD:223021	33/184 (18%)
		LIM1_ZASP_Cypher	595..646	CDD:188838	20/62 (32%)
		LIM2_Enigma_like	654..705	CDD:188748	13/53 (25%)
		LIM3_ZASP_Cypher	713..767	CDD:188844	18/53 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910