DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and ZFHX3

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001373664.1	Gene:	ZFHX3 / 463	HGNCID:	777	Length:	3703	Species:	Homo sapiens

Alignment Length:	786	Identity:	153/786 - (19%)
Similarity:	243/786 - (30%)	Gaps:	315/786 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 VAGSDAALKRKMQLELQVPPHDLDAALCDG------------LTETEAIQLQQ--------YVQK 182
            :|.:.|.::..:|.|||     ..|||...            :|....:||||        |:..
Human  1745 LAQAQAQVQAHLQQELQ-----QQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPS 1804

  Fly   183 LREQC-----------------VGQGVVVRLGDRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPV 230
            ...|.                 .|.|::..|     .|||:      :|.|..||      ::|
Human  1805 AEFQLNPEVSLPVTSGALTLTGTGPGLLEDL-----KAQVQ------VPQQSHQQ------ILP- 1851

  Fly   231 ADDTLNELLANPKVAQ---ALASPASAHP----KLLVAFSEPLCESTAQFEENG----------- 277
             ....|:|    .:||   ||..| |.||    ||::...|...:......|.|
Human  1852 -QQQQNQL----SIAQSHSALLQP-SQHPEKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLP 1910

  Fly   278 -ALRAQTREKLL--GISKPALLS---------------LVTHG----IVYDKVLGILQEK----- 315
             ||:|:.:::|.  |.|:|::|.               |...|    |.|::....:|:|
Human  1911 DALKAKEKKELAPGGGSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTD 1975

  Fly   316 ------KLNISRDPKLGP---IAEFRKEYVNN------------PQFRAEINTICPQPPMTP-IK 358
                  ||......||..   |.:..:|:|:.            .|:|...:.:.|..|.|| ..
Human  1976 QGENLEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPP 2040

  Fly   359 SPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRDPVFAQILQ 423
            .||..|...|||...|        ....||                .:||:......|..|....
Human  2041 PPPPPPPPPPLPAAPP--------QPASTP----------------AIPASAPPITSPTIAPAQP 2081

  Fly   424 AEPLKH--------AFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQSVGLDKNMLQ 480
            :.||..        .|........|...:.:.:|..:..:..|    ||..|||....|:..:||
Human  2082 SVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPL----PADLAQLYQHQLNPTLLQ 2142

  Fly   481 SA---------------------VSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQ 524
            ..                     ::|:|..:::.......|:         |.|.:..|..
Human  2143 QQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGL---------PQKVIKHWFR---- 2194

  Fly   525 LLDEIDKVFADMANGCKDISY-----PKPSLGELPTSQSSDSGFHSKPPTPG------YGSEDLT 578
                 :.:|.:.... ||..|     |..||.||.        ..|:||:|.      :||:  .
Human  2195 -----NTLFKERQRN-KDSPYNFSNPPITSLEELK--------IDSRPPSPEPPKQEYWGSK--R 2243

  Fly   579 AGQGRFAS-----IPGIEDMNMYPSCAGMPEQFQQL-----------------------RLHGDE 615
            :.:.||..     :....|.|.||.    .::|:||                       :.:.::
Human  2244 SSRTRFTDYQLRVLQDFFDANAYPK----DDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQ 2304

  Fly   616 ASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFC 680
            ..||:..|..|               ..||..:....:..|.||....:.:.||:.  ||.:: |
Human  2305 GEGKDGERREL---------------TNDRYIRTSNLNYQCKKCSLVFQRIFDLIK--HQKKL-C 2351

  Fly   681 GRDL---------------AIRLKIPRCRACDELIFTKEYTA-------------------AEE- 710
            .:|.               |:.:..|...:|...:.::.|:|                   |||
Human  2352 YKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAEEL 2416

  Fly   711 ATFHIK 716
            |||:.|
Human  2417 ATFNSK 2422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	18/95 (19%)
		LIM1_Testin_like	627..684	CDD:188726	10/56 (18%)
		LIM2_Testin_like	691..748	CDD:188727	11/46 (24%)
		LIM	755..810	CDD:295319
ZFHX3	NP_001373664.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..536
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..619
		C2H2 Zn finger	673..693	CDD:275368
		C2H2 Zn finger	728..745	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1148..1214
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1303..1354
		C2H2 Zn finger	1362..1385	CDD:275368
		C2H2 Zn finger	1403..1423	CDD:275371
		C2H2 Zn finger	1431..1452	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1529
		C2H2 Zn finger	1547..1571	CDD:275368
		C2H2 Zn finger	1598..1616	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1629..1727
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1865..1938		19/73 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2082		17/75 (23%)
		HOX	2145..2201	CDD:197696	7/73 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2204..2244		14/50 (28%)
		Homeobox	2245..2299	CDD:395001	9/57 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2376..2400		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2422..2520		1/1 (100%)
		COG5576	2594..2738	CDD:227863
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24651376	2615..2617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2619..2647
		Homeobox	2645..2698	CDD:395001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2771..2796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2841..2871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2912..2947
		Homeobox	2950..3003	CDD:395001
		Herpes_BLLF1	<3104..>3191	CDD:282904
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3137..3267
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3386..3449
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3565..3703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910