DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tes and pxna

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_963882.1	Gene:	pxna / 399546	ZFINID:	ZDB-GENE-040105-1	Length:	533	Species:	Danio rerio

Alignment Length:	660	Identity:	154/660 - (23%)
Similarity:	224/660 - (33%)	Gaps:	209/660 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 DLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVVVRLGDRLNHAQVEHVAPALMPTQEAQQTWQ 223
            ||||.|.| |..|.:     ::.|       |||                   .:|    ::|..
Zfish     3 DLDALLAD-LESTTS-----HISK-------QGV-------------------FLP----EETPY 31

  Fly   224 SLGLMPVADDTLNELLANPKV----AQAL-----ASPASAHPKLLVAFSEPLCES--TAQFEENG 277
            |   .|...|:..::.:.|:|    |:.|     ..|.|.|.......|.|...|  .:|.||..
Zfish    32 S---CPRGSDSYQDVSSPPRVISPPAETLNGSWVEKPESKHSSTQSFNSAPKSSSPRVSQSEEEH 93

  Fly   278 ALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGPIAEFRKEYVNNPQFR 342
            ......::|  .|..|.        .|.:..||      .|:|...:|  :.|......:.|.|.
Zfish    94 VYSFPNKQK--SIESPT--------AVMNSSLG------SNLSELDRL--LLELNAVQHSTPSFP 140

  Fly   343 AEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLP 407
            || .|..|:|                                .....|.|...|||::|.  ..|
Zfish   141 AE-ETYPPKP--------------------------------ASNTQRYVPENGVSSVVK--AAP 170

  Fly   408 ANTDYDRDPVFAQIL-QAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQS 471
            ...:..:..:.|::: :..|...:.........|::|.:|::|    .::||||:...|.||.|:
Zfish   171 PKIEKPKRNIPAKVIEEVRPSVESLLNQLESSVPAAVPVSSVP----MVSELRGVQEETPAQQQA 231

  Fly   472 VGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADM 536
                   ..||.|.....|.|..||.|..:   |.::                           |
Zfish   232 -------RISASSATRELDELMASLSDFKV---QSNI---------------------------M 259

  Fly   537 ANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIEDMNMYPSCAG 601
            |.|       |.|    |||            .|..|:: |....|...|     |:|
Zfish   260 AQG-------KSS----PTS------------VPKQGNK-LDNMLGSLQS-----DLN------- 288

  Fly   602 MPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELL 666
                    ||      |..:....:|..|.:||| |:|.....|     .|||..|.|..|:|.:
Zfish   289 --------RL------GVQTVAKGVCGACKKPIA-GQVVTAMGR-----TWHPEHFVCTQCQEEI 333

  Fly   667 ADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQ 731
            ....:|...||.:|.:|.. .|..|||..|...|..|..||.:: |:|.:||.|.||......:.
Zfish   334 GSRNFFERDGQPYCEKDYH-SLFSPRCYYCSGPILDKVVTALDK-TWHPEHFFCAQCGSFFGPEG 396

  Fly   732 YIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHASCFVCAGVQCSKPLIGGR 796
            :  .||.....|...|..:||.:|..|..||  .:..::..:..||..||||.  :|..|.:.|.
Zfish   397 F--HEKEGKAYCRKDYFDMFAPKCGGCARAI--LENYISALNSLWHPECFVCR--ECFTPFVNGS 455

  Fly   797 FCVKENMPFC 806
            |...|..|:|
Zfish   456 FFEHEGQPYC 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	12/37 (32%)
		LIM1_Testin_like	627..684	CDD:188726	19/56 (34%)
		LIM2_Testin_like	691..748	CDD:188727	18/56 (32%)
		LIM	755..810	CDD:295319	17/52 (33%)
pxna	NP_963882.1	Paxillin	54..229	CDD:281527	47/231 (20%)
		LIM1_Paxillin_like	300..352	CDD:259830	20/57 (35%)
		LIM2_Paxillin	359..410	CDD:188791	16/53 (30%)
		LIM3_Paxillin	418..470	CDD:188793	17/52 (33%)
		LIM4_Paxillin	477..528	CDD:188795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910