DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Pxn

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_038945530.1	Gene:	Pxn / 360820	RGDID:	1305759	Length:	1125	Species:	Rattus norvegicus

Alignment Length:	862	Identity:	186/862 - (21%)
Similarity:	289/862 - (33%)	Gaps:	260/862 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 QLEWVPPNAAPDVVTDYME-----KLGTAQIPVAGSDAALKRKMQLELQVPPHDLDAALCDGLTE 170
            :||...|:..|.:..:..|     ::.::|.....|.::..|::.        :|.|:|.|..|.
  Rat   290 ELENSVPSPVPAITVNQGEMSSPQRVTSSQQQTRISASSATRELD--------ELMASLSDFKTS 346

  Fly   171 TEAIQLQQYVQKLREQCVGQGVV--------VRLGDRLNHAQVEHVAPALMPTQEAQQT------ 221
            |.|:.|.           .||::        :.|......:..|...|.::.|:...|.
  Rat   347 TSAMVLS-----------SQGLLPGSTPPLPLTLPPPPTKSSPEDHTPEVLHTEGNGQVLSPSVA 400

  Fly   222 --WQSLGLMPVADDTLNELLANPKVA---QALASPASAHPKLLVA------FSEPLCE------S 269
              |..||.:....||.|.  .:|.|.   |:..:.:.|..:.|::      |..|.|.      |
  Rat   401 PRWLGLGSLEETSDTQNS--RHPSVVASRQSCDAKSQAQVRPLLSGSMGPPFGTPPCHTPYPTGS 463

  Fly   270 TAQ---------FEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKL 325
            ||.         .||......:..:.|.. |||.    :.||:.|....|| :...:.:.|...|
  Rat   464 TASQGPVATHVCLEETAGPTGRWPQALTA-SKPE----IPHGVTYSFQEGI-EPPAVAVDRQAVL 522

  Fly   326 GPIAEFRKEYVNNPQFRAE---INTICP-----------------------------------QP 352
            .......:|.....:.::|   :.:.||                                   :.
  Rat   523 PDTWALTQECGLQERVQSEPGGLGSSCPALGHKEQLGGKRPWKGGLGGPTEALENPGKPEGSMEA 587

  Fly   353 PMTPIKSPP--------GTPFNS----------------------------PLP---------LK 372
            .:.|.|..|        |||..|                            |.|         .:
  Rat   588 ALEPRKEQPELSRAMALGTPSTSERISTSGQIRSVIRRSRETGHVHPMSREPSPRRRLDPATLSR 652

  Fly   373 NP--------VQIRMGAQM---------RQD----------TPMRRVKFGG--VSTIVY--DCGL 406
            ||        :|.|:|.|:         .||          .|..| :.||  |..:||  |..:
  Rat   653 NPSQEQLIAELQGRLGIQLAAEEEAGASAQDWLTEGVVITVQPRGR-QAGGQLVEKVVYPPDSPI 716

  Fly   407 P--ANTDYDRDPVFAQILQAEPLKHAFQEARAGRAP--SSVVISNIPAPVASLAELRGLNPATRA 467
            |  ..|.....|..|.:||..|      :..|..:|  .|:...:.|.|:|..:...|:..|...
  Rat   717 PLRRTTSVVSPPPPAPLLQNHP------DTSASSSPLQPSLPTPSCPGPLAGSSASSGVQTAGEK 775

  Fly   468 QLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKV 532
            ..:..|..    ...:::.|:      ::...|...::..|..||:.         |.|::...|
  Rat   776 PQEEGGRG----PPGLTSVPH------TVRSVGCQTNEDPLFHPMQM---------QGLEQRVDV 821

  Fly   533 FADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIEDMNMYP 597
            ....|.|     :|..|....|..| .:.||.::..|   ||.....|    .|.||.:..:|..
  Rat   822 ERQWAAG-----WPPSSRQSSPEGQ-DEGGFMAQGKT---GSSSPPGG----LSKPGSQLDSMLG 873

  Fly   598 SCAGMPEQFQQLRLHGDEASGKNSTRTI---LCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKC 659
            |            |..|  ..|....|:   :|..|.:||| |:|..   ..||  .|||..|.|
  Rat   874 S------------LQSD--LNKLGVATVAKGVCGACKKPIA-GQVVT---AMGK--TWHPEHFVC 918

  Fly   660 ITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCD 724
            ..|:|.:....:|...||.:|.:|.. .|..|||..|:..|..|..||.:. |:|.:||.|.||.
  Rat   919 THCQEEIGSRNFFERDGQPYCEKDYH-SLFSPRCYYCNGPILDKVVTALDR-TWHPEHFFCAQCG 981

  Fly   725 EPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHASCFVCAGVQCS 789
            .....:.:  .||.....|...|..:||.:|..|..||  .:..::..:..||..||||.  :|.
  Rat   982 AFFGPEGF--HEKDGKAYCRKDYFDMFAPKCGGCARAI--LENYISALNTLWHPECFVCR--ECF 1040

  Fly   790 KPLIGGRFCVKENMPFC 806
            .|.:.|.|...:..|:|
  Rat  1041 TPFVNGSFFEHDGQPYC 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	18/98 (18%)
		LIM1_Testin_like	627..684	CDD:188726	20/56 (36%)
		LIM2_Testin_like	691..748	CDD:188727	18/56 (32%)
		LIM	755..810	CDD:295319	16/52 (31%)
Pxn	XP_038945530.1	Paxillin	121..320	CDD:397550	5/29 (17%)
		LIM1_Paxillin_like	892..944	CDD:259830	21/57 (37%)
		LIM2_Paxillin	951..1002	CDD:188791	16/53 (30%)
		LIM3_Paxillin_like	1010..1062	CDD:188724	16/52 (31%)
		LIM4_Paxillin	1069..1120	CDD:188795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910