DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Limd1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001106208.1	Gene:	Limd1 / 316101	RGDID:	1309830	Length:	663	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	154/735 - (20%)
Similarity:	232/735 - (31%)	Gaps:	224/735 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 TETEAIQLQQYVQKLREQCVGQGVVVRLG-DRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPVAD 232
            |:...|.|||..|   :|.:.:..:.|.| ..:|....:.|:..|                 .||
  Rat    50 TKMAKIHLQQQQQ---QQLLQEEALPRAGRSPINGGNRQGVSSKL-----------------AAD 94

  Fly   233 DTLNELLANPKVAQALASPA----SAHPKLLVAFSEPLCESTAQFEENGALRAQTREKLLGISKP 293
            ......||.|.||..||:..    |::|.     .|.....:|.....|:....:||..:...:|
  Rat    95 GAAKPPLAVPTVAPGLATTTMAVQSSYPP-----QEQRTRPSAHGARPGSQNCGSREGPVSSQRP 154

  Fly   294 ALLSL--------VTHGIVYDKVLGILQEKKLNIS-RDPKLGPIAEFRKEYVNNPQFRAEINTIC 349
            ||..|        :|||..||           |.| ..|:.|...|      .:|.....:.:
  Rat   155 ALHGLGPCEDPSCLTHGDYYD-----------NFSLASPQWGDKPE------ESPSMSLSVGS-- 200

  Fly   350 PQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDR 414
                     ..||.|.|..|..::                              ||       |.
  Rat   201 ---------GWPGCPGNDSLSHRS------------------------------CG-------DS 219

  Fly   415 DPVFAQILQAEPLKHAFQEARAGRAPSSVVISNI-------PAPVASLAELR---------GLNP 463
            .|...|:...           :||:..|...|.|       |..:.|.|..:         ||..
  Rat   220 HPYHPQLSMC-----------SGRSFESGQDSGIGGHSSEKPTGLWSTASSQRVNLGFSSTGLEN 273

  Fly   464 ATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHD-QCHLLQPMKQVHDWLLDDDQLLD 527
            .|.||.:...:...|:.|:.|......|      |..:.:: ...:.:|:.....||.|..:...
  Rat   274 GTPAQPKGTTVSAPMVPSSTSQGACLRR------DSSLGYEAPGRVFKPLVDTQPWLQDGPKSYL 332

  Fly   528 EIDKVFA----------------DMANGCKDI-SYPKP----------------SLGELPTSQSS 559
            .:....:                |...||.:. :.|||                |..|.|.|.|:
  Rat   333 SVSAPLSSTTSKDNAQTGMTAGLDPKLGCVESGTSPKPSPTSNVHPVMSAPSELSCKESPPSWST 397

  Fly   560 DSGFH---SKPPTPG---YGSEDLTAGQGRFASIPGIEDMNMYPSCAGMPEQFQQLRLHGDEASG 618
            ||...   .:.|||.   ...:.||         ||.|   :.||.|.:..:....||..:..:.
  Rat   398 DSSLGPVLPESPTPSRVRLPCQTLT---------PGPE---LGPSTAELKLEALTQRLEREMDAH 450

  Fly   619 KNSTRTILCADCNQPI--------AMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQ 675
            ..:.....|..|::.:        |||::            :|..||.|..|...|....::|..
  Rat   451 PKADYFGACVKCSKGVFGAGQACQAMGDL------------YHDACFTCAACSRKLRGKAFYFVN 503

  Fly   676 GQVFCGRDL---AIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIADEK 737
            |:|||..|.   ..:....||..|..||......|..: ::|...|.|..|:|.|.|..:..|.:
  Rat   504 GKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGK-SYHPGCFRCVICNECLDGVPFTVDSE 567

  Fly   738 SNMPLCLLCYDRLFAVRCQRCKVAIGPADQG-----VAWGDVHWHASCFVCAGVQCSKPL---IG 794
             |...|:..|.::.|.:|..|.:.|.|.:..     |...|..:|..|:.|.  .|...|   .|
  Rat   568 -NKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCE--DCGLELNDEDG 629

  Fly   795 GRFCVKENMPFCSPTCVRSL 814
            .|....|:..||....|:.|
  Rat   630 HRCYPLEDHLFCHSCHVKRL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	8/27 (30%)
		LIM1_Testin_like	627..684	CDD:188726	16/64 (25%)
		LIM2_Testin_like	691..748	CDD:188727	16/56 (29%)
		LIM	755..810	CDD:295319	16/62 (26%)
Limd1	NP_001106208.1	Mediates nuclear export. /evidence=ECO:0000250	54..128		23/98 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..99		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..158		10/45 (22%)
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	180..251		19/135 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..297		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..416		16/80 (20%)
		Interaction with RB1. /evidence=ECO:0000250	391..429		13/49 (27%)
		Necessary for nuclear localization. /evidence=ECO:0000250	459..663		53/207 (26%)
		LIM1_Ajuba_like	459..512	CDD:188738	16/64 (25%)
		LIM2_Ajuba_like	524..576	CDD:188741	15/53 (28%)
		LIM3_Ajuba_like	584..645	CDD:188822	16/62 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810