DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Lmcd1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_659048.1	Gene:	Lmcd1 / 30937	MGIID:	1353635	Length:	365	Species:	Mus musculus

Alignment Length:	744	Identity:	130/744 - (17%)
Similarity:	189/744 - (25%)	Gaps:	422/744 - (56%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LKRSKLGHEAGA-GAPCAECKDKCPGLDLHFWRKVCRNCKCPKIQHVCPD--DDD---------- 80
            :::..||.:..| |..|..||..|.|.:.|.|||:|::|||.:.:|....  |||
Mouse    12 VQKMSLGQQQSARGVACLRCKGMCSGFEPHSWRKICKSCKCSQEEHCLSSDLDDDRKIGRLLMDS 76

  Fly    81 --ATGWAQFEILGQIRAKPAYIKIKALASQP-----------VQLEWVPPNAAPDVVTDYMEKLG 132
              ||..|:.:....||   .|.:.:.:.:.|           :..||.||.....:...|||.:.
Mouse    77 KYATLTARVKGGDGIR---IYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIP 138

  Fly   133 TAQIPVAGSDAALKRKMQLELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVVVRLG 197
            ..:.||.|::.||.|:.||..|:|.:|.|.:.|.||.|.|...::::|:..:.:.:|.|.|.
Mouse   139 KERQPVTGTEGALYRRRQLMHQLPIYDQDPSRCRGLVENELKAMEEFVKHYKSEALGVGEVA--- 200

  Fly   198 DRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASAHPKLLVAF 262
                           :|.|.        ||                            ||
Mouse   201 ---------------LPGQG--------GL----------------------------PK----- 209

  Fly   263 SEPLCESTAQFEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGP 327
                       |||     :|:||
Mouse   210 -----------EEN-----KTQEK----------------------------------------- 217

  Fly   328 IAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRV 392
                                            |.||...:|
Mouse   218 --------------------------------PEGTETTAP------------------------ 226

  Fly   393 KFGGVSTIVYDCGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAE 457

Mouse   227 ----------------------------------------------------------------- 226

  Fly   458 LRGLNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDD 522

Mouse   227 ----------------------------------------------------------------- 226

  Fly   523 DQLLDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASI 587
                         ..||         |||:
Mouse   227 -------------TTNG---------SLGD----------------------------------- 234

  Fly   588 PGIEDMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAW 652
            |..|...:...|.|                         .|..:.|:      |.|||||....|
Mouse   235 PSKEVEYVCELCKG-------------------------AAPVDSPV------VYADRAGYSKQW 268

  Fly   653 HPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKH 717
            ||.||:||.|.|.|.||:||:..|..:|||.....:: |||..|||:||:::|...|:..:|.||
Mouse   269 HPTCFQCIKCSEPLVDLIYFWKDGAPWCGRHYCESVR-PRCSGCDEIIFSEDYQRVEDLAWHRKH 332

  Fly   718 FCCYQCDEPLAGQQYIADEKSNMPLCLLC 746
            |.|..|::.|:|:.||..:  ...||..|
Mouse   333 FICEGCEQLLSGRAYIVTK--GQLLCPTC 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	28/86 (33%)
		LIM1_Testin_like	627..684	CDD:188726	26/56 (46%)
		LIM2_Testin_like	691..748	CDD:188727	23/56 (41%)
		LIM	755..810	CDD:295319
Lmcd1	NP_659048.1	PET_testin	116..203	CDD:193604	28/104 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..231		18/354 (5%)
		LIM1_Testin_like	243..300	CDD:188726	28/87 (32%)
		LIM	306..359	CDD:295319	22/54 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848908
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2802
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001604
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.860