DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Limch1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_038947830.1	Gene:	Limch1 / 305332	RGDID:	1305269	Length:	1561	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	154/791 - (19%)
Similarity:	249/791 - (31%)	Gaps:	286/791 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SPNSCVETPK-----APEWLSKLESRREQLKRSKLGHEAGAGAPCA----ECKDK------CPGL 54
            || |...||.     .|...|:.::.:|.||..|:..:.......|    |.|:|      .||.
  Rat   973 SP-SKTSTPNTVPMLTPRPYSQPKNSQEVLKTFKVDGKVSMNGETARGDVEGKEKEDPTAVAPGP 1036

  Fly    55 DLHFWRKVCRNCKCPKIQHVCPDDDDATGWAQFEILGQIRAKPAYIKIKALASQPVQLEWVPPNA 119
            .|                         |....||.:..:...|..:|   ..|..:::....||:
  Rat  1037 SL-------------------------TKSQMFEGVATVHGSPVQVK---QGSNSIEINIKKPNS 1073

  Fly   120 APDVVTDYMEKL-GTAQIPVAGSDAALKRKMQLELQVPPH-DLDAALCD---GLTE-TEAIQLQQ 178
            .|..:|...|:. ...:....|.:::..|.::|:...|.| ......|.   .|.| :.:.||:.
  Rat  1074 PPQELTAASEETESNGRDDENGEESSGARDVELDSAEPQHFTTTVTRCSPTVALVEFSSSPQLRN 1138

  Fly   179 YVQKLREQCVGQGVVVRLGDRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPVADD----TLN--E 237
            .|.:.::|...:.   .:..::.....:.||....|..||..|:..|..||..|.    .||  |
  Rat  1139 EVPEEQDQKKPEN---EMSGKVELVLSQKVAKPKSPEPEATLTFPFLDKMPETDQLHLPNLNSQE 1200

  Fly   238 LLANPKV------------AQALASPASAHPKLLVAFS----EPLCESTAQFEENGALRAQTREK 286
            |..:..:            :|:..||:|........|.    :|  |...:.:|..   .|.:|:
  Rat  1201 LPGSAPLRVQNSWRRSQFFSQSADSPSSEKSPASTPFKFWAWDP--EEERRRQEKW---QQEQER 1260

  Fly   287 LLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGPIAEFRKEYVNNPQFRAEINTICP- 350
            ||...             |.|     ::.||....:.....:.|..:.|....:...| :|:.|
  Rat  1261 LLQER-------------YQK-----EQDKLKEEWEKAQKEVEEEERRYYEEERKIIE-DTVVPF 1306

  Fly   351 -------QPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPA 408
                   ....|......|:...:.:.|:| .|.| ..:.||:||::
  Rat  1307 TISSSSADQLSTSSSVTEGSGTRNKMDLEN-CQDR-DKERRQNTPLQ------------------ 1351

  Fly   409 NTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQSVG 473
              :.|.|         ..||     ||.         |.:|...:||.:    :|:..:
  Rat  1352 --ENDSD---------SSLK-----ARE---------SGLPEEHSSLTQ----SPSANS------ 1381

  Fly   474 LDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADMAN 538
                  :::||              ||||.||    ||..:..                    |:
  Rat  1382 ------ENSVS--------------KGISQDQ----QPETEAE--------------------AS 1402

  Fly   539 GC-------------KDISYPKPSLGELPTSQSSDSGFHSKPPT-------------PG-----Y 572
            .|             :.||.|       |||:|.|    .||.|             ||     .
  Rat  1403 HCGTNPQSAQDPPWNQQISNP-------PTSKSED----VKPKTLALEKSINHQIESPGERRKKS 1456

  Fly   573 GSEDLTAGQGRFASIPGIEDMNMYPSCAGM-PEQFQQLRLHGDEASGKNSTRTILCADCNQPIAM 636
            ..|:..||.....|          |:..|. |.::::      ..|||.     ||:.|.  :|:
  Rat  1457 PRENFRAGPLSPCS----------PTPPGQSPNRYKR------SISGKK-----LCSSCG--LAL 1498

  Fly   637 GEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIF 701
            |:.|...... ..:.:|..||:|..|:..|.|.|         .|.|:.||..:..|..|    :
  Rat  1499 GKGAAMIIET-LNLYFHIQCFRCGICKGQLGDAV---------SGTDVRIRNGLLNCTDC----Y 1549

  Fly   702 TKEYTAAEEAT 712
            .:..:|.:..|
  Rat  1550 MRSRSAGQPTT 1560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	17/92 (18%)
		LIM1_Testin_like	627..684	CDD:188726	14/56 (25%)
		LIM2_Testin_like	691..748	CDD:188727	4/22 (18%)
		LIM	755..810	CDD:295319
Limch1	XP_038947830.1	CH_LIMCH1	23..140	CDD:409127
		DUF4757	250..>311	CDD:406382
		PRK07764	<276..>412	CDD:236090
		DUF4757	<737..868	CDD:406382
		GBP_C	<1245..1282	CDD:419202	10/57 (18%)
		LIM	1491..1548	CDD:214528	18/68 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900