DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and LMCD1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_055398.1	Gene:	LMCD1 / 29995	HGNCID:	6633	Length:	365	Species:	Homo sapiens

Alignment Length:	748	Identity:	120/748 - (16%)
Similarity:	179/748 - (23%)	Gaps:	430/748 - (57%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LKRSKLGH-EAGAGAPCAECKDKCPGLDLHFWRKVCRNCKCPKIQHVCPDD--DDATGWAQFEIL 90
            :|:..||. ::..|..|..||..|.|.:.|.|||:|::|||.:..|....|  ||..       :
Human    12 VKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRK-------I 69

  Fly    91 GQIRAKPAYIKIKA----------------LASQP-----------VQLEWVPPNAAPDVVTDYM 128
            |::.....|..:.|                :.:.|           :..||.||.....:...||
Human    70 GRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYM 134

  Fly   129 EKLGTAQIPVAGSDAALKRKMQLELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVV 193
            |.:...:.||.|::.|..|:.||..|:|.:|.|.:.|.||.|.|...::::|::.:.:.:|.|.|
Human   135 ELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEV 199

  Fly   194 VRLGDRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASAHPKL 258
            ...|.            ..:|.:|.:|.                  ..|:.|:..|:..
Human   200 ALPGQ------------GGLPKEEGKQQ------------------EKPEGAETTAATT------ 228

  Fly   259 LVAFSEPLCESTAQFEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDP 323
                             ||:|...::|
Human   229 -----------------NGSLSDPSKE-------------------------------------- 238

  Fly   324 KLGPIAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTP 388
                     .|||
Human   239 ---------VEYV---------------------------------------------------- 242

  Fly   389 MRRVKFGGVSTIVYDCGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVA 453

Human   243 ----------------------------------------------------------------- 242

  Fly   454 SLAELRGLNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDW 518
                                                                |.|
Human   243 ----------------------------------------------------CEL---------- 245

  Fly   519 LLDDDQLLDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGR 583
                                 ||         |..|            |.:|
Human   246 ---------------------CK---------GAAP------------PDSP------------- 255

  Fly   584 FASIPGIEDMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGK 648
                                                                    .|.:||||.
Human   256 --------------------------------------------------------VVYSDRAGY 264

  Fly   649 EIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATF 713
            ...|||.||.|..|.|.|.||:||:..|..:|||.....|: |||..|||:||.::|...|:..:
Human   265 NKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLR-PRCSGCDEIIFAEDYQRVEDLAW 328

  Fly   714 HIKHFCCYQCDEPLAGQQYIADEKSNMPLCLLC 746
            |.|||.|..|::.|:|:.||..:  ...||..|
Human   329 HRKHFVCEGCEQLLSGRAYIVTK--GQLLCPTC 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	27/86 (31%)
		LIM1_Testin_like	627..684	CDD:188726	22/56 (39%)
		LIM2_Testin_like	691..748	CDD:188727	23/56 (41%)
		LIM	755..810	CDD:295319
LMCD1	NP_055398.1	PET_testin	116..203	CDD:193604	27/86 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..235		10/87 (11%)
		LIM1_Testin_like	243..300	CDD:188726	30/177 (17%)
		LIM	306..359	CDD:295319	22/54 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3923
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001604
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.860