DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Limd1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_038888.2	Gene:	Limd1 / 29806	MGIID:	1352502	Length:	668	Species:	Mus musculus

Alignment Length:	691	Identity:	147/691 - (21%)
Similarity:	221/691 - (31%)	Gaps:	188/691 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 QEAQQTWQS-----LGLMPV-------------ADDTLNELLANPKVAQALA-SPASAHPKLLVA 261
            |:.||..|.     .|..||             ||......||.|.||..|| :.|:|.|.  ..
Mouse    60 QQQQQLLQEEALPRAGRSPVNGGNRQGASGKLAADGAAKPPLAVPTVAPGLATTTAAAQPS--YP 122

  Fly   262 FSEPLCESTAQFEENGALRAQTREKLLGISKPALLSL---------VTHGIVYDKVLGILQEKKL 317
            ..|.....:|.....|:....:||..:...:|||..|         :|||..||
Mouse   123 SQEQRIRPSAHGARPGSQNCGSREGPVSSQRPALHGLSPSCEDPSCLTHGDYYD----------- 176

  Fly   318 NIS-RDPKLGPIAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGA 381
            |.| ..|:.|          :.|:.       ||...:......||.|
Mouse   177 NFSLASPQWG----------DKPEG-------CPSVSLGVGSGWPGCP----------------- 207

  Fly   382 QMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVIS 446
                         |..||:...||    ..:...|..:.:......:........|....|   |
Mouse   208 -------------GNDSTLPKSCG----DHHPYQPQLSTVCSGRSFESGISGQDGGIGGHS---S 252

  Fly   447 NIPAPVASLAELR---------GLNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGIS 502
            ..|..:.|.|..:         ||...|.||.:...:...|:.|:.|......|      |.|:.
Mouse   253 EKPTGLWSTASSQRVNLGFSSMGLENGTSAQPKGTTVSAPMVPSSASQGACPKR------DSGLG 311

  Fly   503 HDQC-HLLQPMKQVHDWLLDDDQLLDEIDKVFADMAN----------------GCKDI-SYPKPS 549
            ::.. .:.:|:.....||.|..:....:....:..|.                ||.:. :.||||
Mouse   312 YEASGRVFKPLVDTQPWLQDGPKSYLSVSAPLSSTAGKDSTQPGMTTGLDPKFGCVESGTSPKPS 376

  Fly   550 LGELPTS-----QSSDSGFHSKPPTPGYGS----EDLTAGQGRFASI--------PGIEDMNMYP 597
                |||     .|:.|....|..:|.:.:    |.:..|....:.:        ||.|   :.|
Mouse   377 ----PTSNVHPVMSTPSELSCKESSPSWSTDSSLEPVLPGSPTPSRVRLPCQTLAPGPE---LGP 434

  Fly   598 SCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPI--------AMGEVAVKADRAGKEIAWHP 654
            |.|.:..:....||..:..:...:.....|..|::.:        |||::            :|.
Mouse   435 STAELKLEALTQRLEREMDAHPKADYFGSCVKCSKGVFGAGQACQAMGDL------------YHD 487

  Fly   655 GCFKCITCRELLADLVYFFHQGQVFCGRDL---AIRLKIPRCRACDELIFTKEYTAAEEATFHIK 716
            .||.|..|...|....::|..|:|||..|.   ..:....||..|..||......|..: ::|..
Mouse   488 ACFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGK-SYHPG 551

  Fly   717 HFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQG-----VAWGDVHW 776
            .|.|..|:|.|.|..:..|.: |...|:..|.::.|.:|..|.:.|.|.:..     |...|..:
Mouse   552 CFRCVICNECLDGVPFTVDSE-NKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDY 615

  Fly   777 HASCFVCAGVQCSKPL---IGGRFCVKENMPFCSPTCVRSL 814
            |..|:.|.  .|...|   .|.|....|:..||....|:.|
Mouse   616 HVECYHCE--DCGLELNDEDGHRCYPLEDHLFCHSCHVKRL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	16/64 (25%)
		LIM2_Testin_like	691..748	CDD:188727	16/56 (29%)
		LIM	755..810	CDD:295319	16/62 (26%)
Limd1	NP_038888.2	Mediates nuclear export. /evidence=ECO:0000250	54..128		20/69 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..160		23/87 (26%)
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	181..256		17/128 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..309		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..414		16/77 (21%)
		Interaction with RB1. /evidence=ECO:0000250	396..434		6/40 (15%)
		Necessary for nuclear localization. /evidence=ECO:0000250	464..668		53/207 (26%)
		LIM1_Ajuba_like	464..517	CDD:188738	16/64 (25%)
		LIM2_Ajuba_like	529..581	CDD:188741	15/53 (28%)
		LIM3_Ajuba_like	589..650	CDD:188822	16/62 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810