DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and TES

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_056456.1	Gene:	TES / 26136	HGNCID:	14620	Length:	421	Species:	Homo sapiens

Alignment Length:	810	Identity:	173/810 - (21%)
Similarity:	245/810 - (30%)	Gaps:	418/810 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QLKRSKLGHEAGAGAPCAECKDKCPGLDLHFWRKVCRNCKCPKIQH--VCPDDDDATGWAQFE-- 88
            ::|:..||||.|.||||.:||:||.|.:||||||:||||||.:.:|  :..:::|......||
Human     6 KVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDT 70

  Fly    89 ----ILGQIRAK--PAYIKIKALASQP-----------VQLEWVPPNAAPDVVTDYMEKLGTAQI 136
                ::.::::.  |.|.:...:.:.|           |..||.||.....:...||:.|...:.
Human    71 KYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQ 135

  Fly   137 PVAGSDAALKRKMQLELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVVVRLGDRLN 201
            |||||:.|..||.||..|:|.||.|.:.|..|:..|..:::|:|:|.:.:.:|.|.|
Human   136 PVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDV-------- 192

  Fly   202 HAQVEHVAPALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASAHPKLLVAFSEPL 266
                                     .:|
Human   193 -------------------------KLP------------------------------------- 195

  Fly   267 CESTAQFEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGPIAEF 331
            ||..||                                        ..|::||
Human   196 CEMDAQ----------------------------------------GPKQMNI------------ 208

  Fly   332 RKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGG 396
                                         ||                                |.
Human   209 -----------------------------PG--------------------------------GD 212

  Fly   397 VSTIVYDCGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGL 461
            .||                                                 ||.|.
Human   213 RST-------------------------------------------------PAAVG-------- 220

  Fly   462 NPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLL 526
                                             ::.||...|.:
Human   221 ---------------------------------AMEDKSAEHKR--------------------- 231

  Fly   527 DEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIE 591
                                         :|.|
Human   232 -----------------------------TQYS-------------------------------- 235

  Fly   592 DMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPGC 656
                                               |..|...:..|:.|:.|:|||.:..|||.|
Human   236 -----------------------------------CYCCKLSMKEGDPAIYAERAGYDKLWHPAC 265

  Fly   657 FKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCY 721
            |.|.||.|||.|::||:...:::|||......| |||..||||||:.|||.||...:|:|||||:
Human   266 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEK-PRCAGCDELIFSNEYTQAENQNWHLKHFCCF 329

  Fly   722 QCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHAS--CFVCA 784
            .||..|||:.|:.  .::.|:|..||.:..||.||.|..||.|..|.|.:.:..||||  ||:|:
Human   330 DCDSILAGEIYVM--VNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCS 392

  Fly   785 GVQCSKPLIGGRFCVKENMPFCSPTCVRSL 814
              .|||.|||.:|...|.|.|||..|.:.:
Human   393 --CCSKCLIGQKFMPVEGMVFCSVECKKRM 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	32/86 (37%)
		LIM1_Testin_like	627..684	CDD:188726	25/56 (45%)
		LIM2_Testin_like	691..748	CDD:188727	29/56 (52%)
		LIM	755..810	CDD:295319	27/56 (48%)
TES	NP_056456.1	PET_testin	109..196	CDD:193604	33/156 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..164		15/30 (50%)
		LIM1_Testin	236..293	CDD:188797	25/56 (45%)
		LIM2_Testin	299..354	CDD:188800	29/56 (52%)
		LIM3_Testin	361..419	CDD:188803	28/59 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158513
Domainoid	1	1.000	49	1.000	Domainoid score	I11790
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41051
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3923
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001604
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860