DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and Zyx

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001276546.1	Gene:	Zyx / 22793	MGIID:	103072	Length:	564	Species:	Mus musculus

Alignment Length:	583	Identity:	115/583 - (19%)
Similarity:	183/583 - (31%)	Gaps:	176/583 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 PKVAQALASPASAHPKLLVAFSEPLCESTAQFEENGA------LRAQTREKLLGISKPALLSLVT 300
            |.:.:....||.....:..:...||       ||.|.      |..|.|||:..|
Mouse    98 PPMIEEPFPPAPLEEDIFPSPPPPL-------EEEGGPEAPTQLPPQPREKVCSI---------- 145

  Fly   301 HGIVYDKVLGILQEKKLNISRDPKLGPIAEFRKEYVNNPQFRAEINT-ICPQPPMTPIKSPPGTP 364
                                 |.::..::....:...|..|:|.::: ..|.|..||....|.|.
Mouse   146 ---------------------DLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFVPKPSTK 189

  Fly   365 ----FNSPL-PLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRDPVFAQILQA 424
                ..:|| |.|.|       ...|..|..:.|              ........|.....:|.
Mouse   190 PAPGGTAPLPPWKTP-------SSSQPPPQPQAK--------------PQVQLHVQPQAKPHVQP 233

  Fly   425 EPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQSVGLDKNMLQSAVSNAPYY 489
            :|:..|..:.|.       .:|..|.|....|.:                           ||
Mouse   234 QPVSSANTQPRG-------PLSQAPTPAPKFAPV---------------------------AP-- 262

  Fly   490 DRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADMANGCKDISYPKPSLGEL- 553
                                                  :...|.:..:.|......|:|:...:
Mouse   263 --------------------------------------KFTPVVSKFSPGAPSGPGPQPNQKMVP 289

  Fly   554 PTSQSSDSGFHSKPPTPGYG--SEDLTAGQGRFASIPGIEDMNMYPSCAG-----------MPEQ 605
            |.:.||.|....:||:..|.  .|.....:.:....|..::.|...|..|           :.:.
Mouse   290 PDAPSSVSTGSPQPPSFTYAQQKEKPLVQEKQHPQPPPAQNQNQVRSPGGPGPLTLKEVEELEQL 354

  Fly   606 FQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLV 670
            .|||....:....::......|..||||:|..:.||:|  .|:  .:|..||.|..|::.|....
Mouse   355 TQQLMQDMEHPQRQSVAVNESCGKCNQPLARAQPAVRA--LGQ--LFHITCFTCHQCQQQLQGQQ 415

  Fly   671 YFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIAD 735
            ::..:|..:|.......|:  :|..|.:.|..:...|..:| :|.:.|.|..|..||.|..:|.|
Mouse   416 FYSLEGAPYCEGCYTDTLE--KCNTCGQPITDRMLRATGKA-YHPQCFTCVVCACPLEGTSFIVD 477

  Fly   736 EKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQG------VAWGDVHWHASCFVCAGVQCSKPL 792
            : :|.|.|:..|.:.:|.||..|...|.| :.|      |...|.::|..|:.|.  .|.|||
Mouse   478 Q-ANQPHCVPDYHKQYAPRCSVCSEPIMP-EPGRDETVRVVALDKNFHMKCYKCE--DCGKPL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	18/56 (32%)
		LIM2_Testin_like	691..748	CDD:188727	17/56 (30%)
		LIM	755..810	CDD:295319	14/44 (32%)
Zyx	NP_001276546.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..141		11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..344		44/276 (16%)
		PHA03247	<175..368	CDD:223021	44/287 (15%)
		LIM	343..429	CDD:351770	21/89 (24%)
		LIM2_Zyxin	436..495	CDD:188739	19/60 (32%)
		LIM3_Zyxin	496..562	CDD:188819	14/44 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810