DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tes and prkl-1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_741435.2	Gene:	prkl-1 / 177463	WormBaseID:	WBGene00022727	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	386	Identity:	113/386 - (29%)
Similarity:	166/386 - (43%)	Gaps:	98/386 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 PAPVASLAELRGLNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMK 513
            |..::|.....||:||:|.                       |:....|....|.|
Worm    18 PQLISSRRAQGGLSPASRI-----------------------RIAADAHRHSTSDD--------- 50

  Fly   514 QVHDWLLDDDQLLDEIDKVFADMANGCKDISYPKPSLGE-----LPTSQSSDSGFHSKPPTPGYG 573
                   |....|||    :|.:.:|.      ||::..     ||         .:|.|..|..
Worm    51 -------DSGCALDE----YAWVPSGL------KPNMVHAYFACLP---------ENKVPFIGSA 89

  Fly   574 SEDLTAGQGRF------ASIPGIEDMNMYPSCAGMPEQFQQLRL----HGDEASGKNSTR----T 624
            .|.....|.|:      :.:...||:|        .|:...||:    ...|..|....:    .
Worm    90 GEKWRQRQSRYQLPPQDSDVRYCEDLN--------AEEADTLRMFERTRKTECLGSGVVQYAPFD 146

  Fly   625 ILCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLK 689
            ..|..|.:.:..||::|.|.|.||.  :||.||:|.||..||.||:||.|..|::|||..|.::|
Worm   147 TKCEKCPKRLEEGEISVMAARTGKR--YHPSCFRCQTCDVLLVDLIYFAHDNQIYCGRHHAEQVK 209

  Fly   690 IPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAV- 753
             |||..|||:||..|...||..::|..||.|.||::.||.|:|:  :::|.|:||.|:....:.
Worm   210 -PRCAKCDEVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKYM--QRANKPVCLKCFHSSSSTF 271

  Fly   754 RCQRCKVAIGPADQGVAWGDVHWHAS--CFVCAGVQCSKPLIGGRFC-VKENMPFCS-PTC 810
            .|..|:::.......::.||:|||||  ||.|.  .|||.|:|.::. |.|:: ||. .||
Worm   272 SCTTCRLSFSSDTPHMSQGDLHWHASAECFCCC--VCSKNLLGVKYSRVGESL-FCGYQTC 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	27/56 (48%)
		LIM2_Testin_like	691..748	CDD:188727	26/56 (46%)
		LIM	755..810	CDD:295319	21/58 (36%)
prkl-1	NP_741435.2	PET_Prickle	48..144	CDD:193602	26/138 (19%)
		LIM1_Testin_like	149..204	CDD:188726	27/56 (48%)
		LIM2_Testin_like	210..262	CDD:188727	24/53 (45%)
		LIM	283..324	CDD:295319	17/43 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910