DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tes and PRICKLE1

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001138353.1	Gene:	PRICKLE1 / 144165	HGNCID:	17019	Length:	831	Species:	Homo sapiens

Alignment Length:	325	Identity:	112/325 - (34%)
Similarity:	153/325 - (47%)	Gaps:	64/325 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   528 EIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGF----HSKPPTPGYGSEDLTAGQGRFASIP 588
            |::...:.:|.||:..|           :...|||.    ::..| ||...|.:   |..||.:|
Human     4 EMEPKMSKLAFGCQRSS-----------TSDDDSGCALEEYAWVP-PGLRPEQI---QLYFACLP 53

  Fly   589 GIEDMNMYPSCAGMPEQFQQLRL----HGD-------------------------EASGKNSTRT 624
              |:...|.:..|...:.:||..    |.:                         ||.|:.:.:.
Human    54 --EEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKL 116

  Fly   625 I-------LCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGR 682
            :       :|..|...|..|||||.|.|||..:.|||.||.|.||.|||.||:||:..|::.|||
Human   117 LSRAVMHAVCEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGR 181

  Fly   683 DLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIADEKSNMPLCLLCY 747
            ..|..|| |||.||||:||..|.|.||...:|:|||||.:|:..|.||:||.  |...|.|..|:
Human   182 HHAELLK-PRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIM--KDGRPFCCGCF 243

  Fly   748 DRLFAVRCQRCKVAIGPADQGVAWGDVHWHA--SCFVCAGVQCSKPLIGGRFCVKENMPFCSPTC 810
            :.|:|..|:.|...||.....:.:...||||  :||.||  ||...|:|..|..|:...:||.||
Human   244 ESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCA--QCKASLLGCPFLPKQGQIYCSKTC 306

Fly 811 810
Human 307 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	31/56 (55%)
		LIM2_Testin_like	691..748	CDD:188727	29/56 (52%)
		LIM	755..810	CDD:295319	20/56 (36%)
PRICKLE1	NP_001138353.1	PET_Prickle	22..118	CDD:193602	20/101 (20%)
		LIM1_Prickle_1	126..184	CDD:188867	31/57 (54%)
		LIM2_Prickle	189..244	CDD:188802	29/56 (52%)
		LIM3_Prickle	249..307	CDD:188804	22/60 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750