DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and PDLIM5

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001243355.2	Gene:	PDLIM5 / 10611	HGNCID:	17468	Length:	625	Species:	Homo sapiens

Alignment Length:	477	Identity:	105/477 - (22%)
Similarity:	179/477 - (37%)	Gaps:	107/477 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 PFNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDYDRDPV-----FAQILQ 423
            |.:.|.|...|..:.:|:|:        .....|:| .|. .|.::|....|..     |:..
Human   213 PKSGPHPPATPQVLTIGSQV--------ATLSKVAT-TYS-SLSSSTGNVEDSFEGFRNFSTF-- 265

  Fly   424 AEPLKHAFQEARAGRAPSSVVISN-----IPAPVASLAELRGLNPATRAQLQSVGLDKNMLQSAV 483
            :.|.:::.....:..|..|.||:.     .|....||.:...::|.::.      |..:.|||:.
Human   266 SSPARYSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKP------LAFSYLQSSR 324

  Fly   484 SNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDK---------------VF 533
            .:.       .|:|.|..|:.|    :|..|:...:.....:.:.:|.               .|
Human   325 KST-------GSIHVKKTSNSQ----EPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAF 378

  Fly   534 ADMANG--CKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIEDMNMY 596
            ..:.:.  .|..|:.:|:.|...|.:.|:|..:|....|.    :...||.:    |..:| .:.
Human   379 KPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPA----NSALGQTQ----PSDQD-TLV 434

  Fly   597 PSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPI------AMGEVAVKADRAGKEIAWHPG 655
            .....:|             :||   ||.:||.|||.|      |:|:            :|||.
Human   435 QRAEHIP-------------AGK---RTPMCAHCNQVIRGPFLVALGK------------SWHPE 471

  Fly   656 CFKCITCRELLADLVYFFHQGQVFCGRDLAI-RLKIPRCRACDELIFTKEYTAAEEATFHIKHFC 719
            .|.|..|:..:|.:.:...:|.::|  :|.. :...|.|..|...|. .|..:|.:.|:|:..|.
Human   472 EFNCAHCKNTMAYIGFVEEKGALYC--ELCYEKFFAPECGRCQRKIL-GEVISALKQTWHVSCFV 533

  Fly   720 CYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHASCFVCA 784
            |..|.:|:....:..::  ..|.|...|..||...|..|:..|...|..:......||.:||||:
Human   534 CVACGKPIRNNVFHLED--GEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCS 596

  Fly   785 GVQCSKPLIGGRFCVKENMPFC 806
              .|.:.|.|..|..|::.|.|
Human   597 --VCCESLEGQTFFSKKDKPLC 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	17/62 (27%)
		LIM2_Testin_like	691..748	CDD:188727	14/56 (25%)
		LIM	755..810	CDD:295319	17/52 (33%)
PDLIM5	NP_001243355.2	PDZ_signaling	10..82	CDD:238492
		DUF4749	105..201	CDD:406377
		LIM1_ENH	449..500	CDD:188837	18/64 (28%)
		LIM	508..559	CDD:413332	13/53 (25%)
		LIM3_ENH	567..621	CDD:188843	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910