DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tes and pxn

DIOPT Version :9

Sequence 1:	NP_611215.1	Gene:	Tes / 36965	FlyBaseID:	FBgn0034223	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_031752049.1	Gene:	pxn / 100216044	XenbaseID:	XB-GENE-941407	Length:	1070	Species:	Xenopus tropicalis

Alignment Length:	524	Identity:	121/524 - (23%)
Similarity:	178/524 - (33%)	Gaps:	157/524 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 LQEKKLNISRDPKLGPIAEFRKEYVNNPQFRAEINT-ICPQPPMTPIKSP---PGTP-------- 364
            |..|..::|..|   |....|...|:.....|:.:. :.|.||:.||:||   |.:|
Frog   607 LMRKSFSVSSSP---PGTVHRTRLVSKSTSPAQPSACVPPPPPLPPIQSPAFIPHSPQQFPSWKA 668

  Fly   365 -------FNSPLPLKNPVQIRMGAQMRQDTPMRRVKFGGVSTIVYDCGLPANTDY-------DRD 415
                   .:.||||.:..:: ...:....:|::.              ||.|..:       |..
Frog   669 AGDDYQDLSRPLPLPHNKEL-SATRFLPPSPLKT--------------LPPNKSFVSVGCQTDET 718

  Fly   416 PVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQLQSVGLDKNMLQ 480
            |:|..|....|  .....|...|.|.|   ..:|...:.|..:..|.|...
Frog   719 PLFPPIQLISP--QTCSPALFARPPPS---PTLPDKSSGLVLVPSLWPHPE-------------- 764

  Fly   481 SAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLDDDQLLDEIDKVFADMANGCKDISY 545
                     :|...|..|...|..:|  |.|.              ::|..:   ||.| |.:|.
Frog   765 ---------ERHLTSNSDMFPSSSKC--LAPS--------------NDIPSI---MAKG-KSVSN 800

  Fly   546 PKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIEDMNMYPSCAGMPEQFQQLR 610
            ..|                |..|.||...:::.   |...|     |:|
Frog   801 SPP----------------SNTPKPGSQLDNML---GSLQS-----DLN---------------- 825

  Fly   611 LHGDEASGKNSTRTI---LCADCNQPIAMGEVAVKADRAGKEIAWHPGCFKCITCRELLADLVYF 672
                    |....|:   :|..|.:||| |:|..   ..||  .|||..|.|..|:|.:....:|
Frog   826 --------KLGVATVAKGVCGACKKPIA-GQVVT---AMGK--TWHPEHFVCTHCQEEIGSRNFF 876

  Fly   673 FHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIKHFCCYQCDEPLAGQQYIADEK 737
            ...||.:|.:|.. .|..|||..|:..|..|..||.:. |:|.:||.|.||......:.:  .|:
Frog   877 ERDGQPYCEKDYH-NLFSPRCFYCNGPILDKVVTALDR-TWHPEHFFCAQCGAFFGPEGF--HER 937

  Fly   738 SNMPLCLLCYDRLFAVRCQRCKVAIGPADQGVAWGDVHWHASCFVCAGVQCSKPLIGGRFCVKEN 802
            .....|...|..:||.:|..|..||  .:..::..:..||..||||.  :|..|.|.|.|...:.
Frog   938 DGKAYCRKDYFDMFAPKCGGCTHAI--LENYISALNTLWHPECFVCR--ECFTPFINGSFFEHDG 998

  Fly   803 MPFC 806
            .|:|
Frog   999 QPYC 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604
		LIM1_Testin_like	627..684	CDD:188726	20/56 (36%)
		LIM2_Testin_like	691..748	CDD:188727	17/56 (30%)
		LIM	755..810	CDD:295319	17/52 (33%)
pxn	XP_031752049.1	Paxillin	45..234	CDD:397550
		LIM1_Paxillin_like	837..889	CDD:259830	21/57 (37%)
		LIM2_Paxillin	896..947	CDD:188791	15/53 (28%)
		LIM3_Paxillin_like	955..1007	CDD:188724	17/52 (33%)
		LIM4_Paxillin	1014..1065	CDD:188795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910