DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10764 and CG30091

DIOPT Version :9

Sequence 1:	NP_611213.2	Gene:	CG10764 / 36962	FlyBaseID:	FBgn0034221	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_725484.1	Gene:	CG30091 / 246449	FlyBaseID:	FBgn0050091	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	174/535 - (32%)
Similarity:	259/535 - (48%)	Gaps:	81/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KFLETPCGISTR--PKISGGDDAAEPNSIWMAAIFNSSDFQCGGTIIHMRFVLSAAH-------C 79
            :.|:..||:..:  |||.||.||.|..:.|||.|..:.:|.|||::|..:|||:|||       |
  Fly    21 RLLDEDCGVPMQLIPKIVGGVDAGELKNPWMALIKTNDEFICGGSVITNKFVLTAAHCMCTDEEC 85

  Fly    80 LVRGYDLYVRLGARNI------NEPAAVHTVINVFVHHDFIASEYRNDIGLLQLSESIVYTVRVQ 138
            :|:...|.|.||..::      |.|..::.|..|::|..|....|||||.||:|.:||||..:::
  Fly    86 IVKYTQLTVTLGVYHLLATGEHNHPHEIYNVERVYIHDSFAIQNYRNDIALLRLQKSIVYKPQIK 150

  Fly   139 PICIFLDPALKGSVEKLKTFRALGWG-NRNGKLSIMLQTIYLLHLKRNECKRKLNFNLNSRQICA 202
            |:||.|:..||...:.::.|.|:||| ..|||:|..||.:.:..:.|..|:....:..:....||
  Fly   151 PLCILLNDQLKPQTDLIQEFTAIGWGVTGNGKMSNNLQMVKIYRIDRKMCEAAFWYTFDYPMFCA 215

  Fly   203 GTKNG-DTCRGDSGGPLSTNILFPSNKSYEVQLGIVSFGDPECRGVGVYTDVTSYVDWISSTIAR 266
            ||..| |||:.||||||..::||...|. ..||||||.|..:|||.|:||||..::|:|...:..
  Fly   216 GTAVGRDTCKRDSGGPLYIHMLFDGIKR-ATQLGIVSTGTEDCRGFGMYTDVMGHIDFIERIVLD 279

  Fly   267 ND------YLPIGVSGGDIAMGNPIAPDANRHWTPAASPPLPSMLYNSCSQDIAAPIAQLRIYW- 324
            .|      |:.:..:|   .:||    |....|                  |.:.|.|.....|
  Fly   280 ADIEVVLPYIDLLDAG---CLGN----DTLNSW------------------DRSGPDAIRSFEWL 319

  Fly   325 ----PGSYAV--GVLITDQLIIAAATDLPTVAAYLYVFVVLEGISAINQIESVSKHPNFTTNDYR 383
                ..|:.:  |.||:...::..| .|.:.:..|.| .:.:|......:.||.|||.|.:. .:
  Fly   320 AEVYKDSFIISNGALISKTFVVTTA-QLISESTALKV-QLGQGDVHTYAVASVHKHPKFVSL-AQ 381

  Fly   384 NDIAVLKLVRSISST-AMKPICI--LTTQIYQQN-----AEKARELKIIDTDLAEQFDVRLMEGS 440
            ||||:|||...:..| :::|||:  |:.:..||.     |:.|..|..:.........||....|
  Fly   382 NDIALLKLGEEVQYTESIRPICLPSLSNKAEQQKFQRRAADPALNLIAVGWGTPTNVVVRRTNAS 446

  Fly   441 QCAKHLGFQINENQVCMVDPSDTSNPRQKRSYI---VVGGMNANGQIRYILVGIFSFS-----SK 497
            :|.:.....|.|.|:||..||    |...|..|   :|..:....:..:.|||:.||.     :.
  Fly   447 KCYREDHQDIGEQQLCMESPS----PHLLRVGIGSPLVNPLTHGNRRAFSLVGLASFGRLEPFAS 507

  Fly   498 NILVFTNVMRHTDWI 512
            |  |:|||:.:.|||
  Fly   508 N--VYTNVLEYLDWI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10764	NP_611213.2	Tryp_SPc	37..260	CDD:214473	98/237 (41%)
		Tryp_SPc	38..263	CDD:238113	98/239 (41%)
		Tryp_SPc	317..512	CDD:214473	60/217 (28%)
		Tryp_SPc	317..512	CDD:304450	60/217 (28%)
CG30091	NP_725484.1	Tryp_SPc	36..273	CDD:214473	98/237 (41%)
		Tryp_SPc	37..276	CDD:238113	98/239 (41%)
		Trypsin	310..520	CDD:278516	61/218 (28%)
		Tryp_SPc	313..520	CDD:304450	59/215 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463407
Domainoid	1	1.000	102	1.000	Domainoid score	I4289
eggNOG	1	0.900	-	-		E33208_3BQ4K
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4468
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000404
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24260
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890