DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10764 and CG42694

DIOPT Version :9

Sequence 1:	NP_611213.2	Gene:	CG10764 / 36962	FlyBaseID:	FBgn0034221	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001188994.1	Gene:	CG42694 / 10178792	FlyBaseID:	FBgn0261584	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	170/525 - (32%)
Similarity:	260/525 - (49%)	Gaps:	42/525 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLTLCVTENE-HFKFLETPCG--ISTR--PKISGGDDAAEPNSIWMAAIFNSSDFQCGGTIIHMR 71
            ||.|.|.::. :.|||:..||  ||.:  .|:      .:|.:.|:|.|.|.:...|.|::|..:
  Fly     8 LLMLTVLQSHVNSKFLDDYCGAPISNQSITKL------RQPQAGWLAHISNGTHVLCSGSLISKQ 66

  Fly    72 FVLSAAHCL-VRGYDLYVRLGARNINEPAAVHTVINVFV-HHDFIASEYRNDIGLLQLSESIVYT 134
            ||||||.|: |.| .|:|:||..|..:....:||.||.: .|.  ....:.|||||:||:|:.|.
  Fly    67 FVLSAAQCIDVHG-KLFVQLGVSNATKSPHWYTVSNVVIPSHS--GKRLQRDIGLLKLSQSVDYN 128

  Fly   135 VRVQPICIFLDPALKGSVEKLKTFRALGWGNRNGKLSIMLQTIYLLHLKRNECKRKLNFNLNSRQ 199
            ..|.||||.|:......|:.|:.|....|.::|..    .|||.|..|.|:.||..|:.|:..::
  Fly   129 DFVYPICIALNTNTLDMVKILQNFTTSAWLSKNKN----PQTIVLSQLSRDRCKLNLSGNVTPKE 189

  Fly   200 ICAGT-KNGDTCRGDSGGPLSTNILFPSNKSYEVQLGIVSF--GDPECRGVGVYTDVTSYVDWIS 261
            |||.: :..::|..|||..|:..|:..||...|:..||..:  |...|....:|.||...|.||.
  Fly   190 ICAASLQRNNSCFIDSGSALTQPIIQGSNIVREMLFGIRGYVNGRSWCSEPAIYIDVAECVGWIE 254

  Fly   262 STIARNDYLPIGVSGGDIAMGNPIAPDANRHWTPAASPPLPS-MLYNSCSQDIAAPIAQLRIYWP 325
            :.:.:.|    |.....:|     .|:.|:|...:.|....: :|:.:|..:......:.|||.|
  Fly   255 TVVQQYD----GTDSRAVA-----TPEVNQHLKHSLSRMGKNILLFKNCRGNSLQSKLRARIYGP 310

  Fly   326 GSYAVGVLITDQLIIAAATDLPTVAAYLYVFV--VLEGISAINQIESVSKHPNFTTNDYRNDIAV 388
            .....|..||.:.:|..|.|||..|..|||.:  .|......: ::||.|||.| :.||:||||:
  Fly   311 NYIGQGWFITHRFVITNAKDLPESAESLYVGLPGTLRSYDEFS-VQSVFKHPEF-SEDYKNDIAL 373

  Fly   389 LKLVRSISSTAMKPICILTTQIYQQNAEKARELKIIDTDLAEQFDV-----RLMEGSQCAKHLGF 448
            |::.:.::...::|||:|..:..|:.|:.:..:.......|.:..|     .|.:...|...|..
  Fly   374 LRVHQRVAMGHLRPICMLLKENQQELAKSSPPISFDYVQTANRIQVVRKIDALADPRICTNRLLK 438

  Fly   449 QINENQVCMVDPSDTSNPRQKRSYIVVGGMNANGQIRYILVGIFSFSSKNILVFTNVMRHTDWIL 513
            .|..||:|:|.|.:|......|..|:...|..:|:...||.||.|:|..:|.||||||.||.||.
  Fly   439 TIEPNQLCVVVPPETVQKNATRGGILGLRMMYSGKEWLILFGISSYSHNDIEVFTNVMEHTQWIA 503

  Fly   514 SLLYS 518
            :::.|
  Fly   504 NVVNS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10764	NP_611213.2	Tryp_SPc	37..260	CDD:214473	78/227 (34%)
		Tryp_SPc	38..263	CDD:238113	79/229 (34%)
		Tryp_SPc	317..512	CDD:214473	67/201 (33%)
		Tryp_SPc	317..512	CDD:304450	67/201 (33%)
CG42694	NP_001188994.1	Tryp_SPc	46..256	CDD:304450	78/216 (36%)
		Tryp_SPc	46..253	CDD:214473	76/213 (36%)
		Tryp_SPc	319..505	CDD:304450	64/187 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463231
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I7012
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000404
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24260
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.990