DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and adgrg4a

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_021336868.1	Gene:	adgrg4a / 793963	ZFINID:	ZDB-GENE-121129-2	Length:	1201	Species:	Danio rerio

Alignment Length:	431	Identity:	92/431 - (21%)
Similarity:	158/431 - (36%)	Gaps:	102/431 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 QYQKMQKSKCYGDMSED-ELNKHDPFVNVTLSDGS-------VVRRHF--KEDLIVQSDLAKPGC 148
            |:....|.|.:.|.|.: .||.:....:||.:..|       |..||.  |||.    |:.|  |
Zfish   758 QFHFYGKEKLFEDTSSNLTLNSYVVSASVTNATVSELEIPVMVTLRHLQNKEDW----DIVK--C 816

  Fly   149 PRMYFLNHELPGNEFTLFENGSLLRHWD-------KVELSKREYCVQHLSFKDDSIRIAPHF--- 203
            ....|..::..|.             |:       ....::......||:          ||
Zfish   817 VYWDFNKNDKKGG-------------WNDRGCEIVNSNATQTSCSCDHLT----------HFGVL 858

  Fly   204 -----CPLSSEHSRTWKTVAIV---ISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFF 260
                 .|::.:.......::.|   ||.|.:.:|:..||..||||..:....:..|....||...
Zfish   859 LDISKTPINPKDEWVLTIISYVGCGISSIFLGVTLLTYLAFEKLRRDYPSKILINLCMALLGLNM 923

  Fly   261 LVL-NVW---KYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSY 321
            |.| |.|   ..|:..|:|.....::..:|.|.|:.:.::   |.:.......|.::| :..|.:
Zfish   924 LFLVNSWFASFNSNALCITVAAFQHYFFLATFTWMGLGAI---NMYLALVKVFNSYVP-SYILKF 984

  Fly   322 NLYAWGMALLLTAITYIAD-----QVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVF 381
            ....||:.|.:..:....|     ..:..:.|:.....   || :..|:|..:......:||:|.
Zfish   985 CAVGWGIPLSVVILVLAIDFNSYGTSLSTDLLQESTAF---CW-FKNDVTFYVTVVSFAILIMVC 1045

  Fly   382 NITMFVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLR----LFIIMGLSWSLEIISFL 442
            ||.:||:...:|.|::            .|:.:|.::.:...||    |..::||:|   |:.|.
Zfish  1046 NIIVFVVVLVQIHKMR------------VNKPSSSRKGFLHDLRVVASLTFLLGLTW---ILVFF 1095

  Fly   443 LSKNQAWAKA----FMVADYFNWSQGTVIFLLFVLRPSTLK 479
                 .|..|    ..:....|..||..|||.:.|....::
Zfish  1096 -----GWGPAKTPLMYLFSILNSLQGFFIFLFYCLMKDNVR 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	26/134 (19%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	54/235 (23%)
adgrg4a	XP_021336868.1	LamG	50..210	CDD:328935
		HsdR	<637..>729	CDD:333053
		GPS	815..858	CDD:307782	9/67 (13%)
		7tmB2_GPR112	871..1138	CDD:320663	65/289 (22%)
		TM helix 1	873..898	CDD:320663	6/24 (25%)
		TM helix 2	908..930	CDD:320663	6/21 (29%)
		TM helix 3	941..968	CDD:320663	5/29 (17%)
		TM helix 4	983..999	CDD:320663	3/15 (20%)
		TM helix 5	1028..1051	CDD:320663	7/22 (32%)
		TM helix 6	1073..1098	CDD:320663	8/32 (25%)
		TM helix 7	1102..1127	CDD:320663	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910