DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and adgre5b.3

DIOPT Version :10

Sequence 1:NP_663308.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_005160275.1 Gene:adgre5b.3 / 792970 ZFINID:ZDB-GENE-121214-275 Length:756 Species:Danio rerio


Alignment Length:509 Identity:104/509 - (20%)
Similarity:192/509 - (37%) Gaps:123/509 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 IRFCCPQYQ----KMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGC 148
            :|...||.:    ||:....|.:::... |:..|..:||||.||.   ||..........:.||.
Zfish   278 MRLIGPQLKDPVTKMETQNTYAEVAVTR-NQTPPSGSVTLSTGSA---HFNTSWETVVGKSYPGF 338

  Fly   149 PRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCV--------------QHLS------FK 193
            ..:..::::...:...||  .|:.|....|:..:..|.:              :|||      |.
Zfish   339 AFVALVSYKDMNSSSDLF--NSMAREKSDVKEKQITYKLNSKVVTAVVSNPDTKHLSKPVTLIFT 401

  Fly   194 DDSIRI----APHFCPLSSEHSRTWK--------------------------------------- 215
            .:..|.    ..:.|...||..|.|.                                       
Zfish   402 HEEKRAESEGVAYSCVYWSESERGWSGRGCELAWSNSTHTACSCSHLSSFAVLMALYPVEDTFEL 466

  Fly   216 ----TVAIVISLICIILTISVYLY---VEKLRN-LHGKCFIC-YLASLFLGYFFLVLNVWKYSSG 271
                .|.:|:||||:||.|..:.:   ::..|| :|....:| ::|.|   .|...::.......
Zfish   467 VVITRVGLVLSLICLILCILTFRFCRSIQGTRNSIHLHLSVCLFIADL---VFLCGISSTHNQVA 528

  Fly   272 FCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAIT 336
            ..:.||.|.:| .::||.|:.:..:.|:...      :..|....:.|......:|:.|::.:|:
Zfish   529 CAIVAGLLHFF-FLSAFCWMLLEGVQLYRMV------VLVFHTTLKHLYMYAVGYGVPLVIVSIS 586

  Fly   337 YIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQ 401
            .||  |.|.      .|..::||:......::.:|. |:.:|::.|||:|::|.:::      |.
Zfish   587 AIA--VPKG------YGTDRHCWLSLEGYLILSFFI-PVCIIVILNITVFIITVWKL------AL 636

  Fly   402 NFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKN--QAWAKAFMVADYFNWSQG 464
            .|:......::|:..:...|..:....::|.||....  ||..||  :.....|::   .|..||
Zfish   637 KFSSLNPDLSKLHKIRSFLATAVAQLCVLGGSWVFGF--FLFQKNGTEVMLYLFII---LNSLQG 696

  Fly   465 TVIFLLFVL---------RPSTLKLLKERIKGGRDEAGASDEHISLQNTKIDPS 509
            .:||::..|         |...:::...:.||....:.....|.|.:..:||.|
Zfish   697 ALIFIMHCLLSKQVRVEYRSLFMRMCSNKKKGDYSVSSTEPSHSSQKPLQIDQS 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_663308.1 Methuselah_N 26..204 CDD:429053 29/143 (20%)
7tmB3_Methuselah-like 208..486 CDD:410632 67/336 (20%)
TM helix 1 210..235 CDD:410632 11/67 (16%)
TM helix 2 244..266 CDD:410632 4/22 (18%)
TM helix 3 274..301 CDD:410632 8/26 (31%)
TM helix 4 318..338 CDD:410632 4/19 (21%)
TM helix 5 364..393 CDD:410632 8/28 (29%)
TM helix 6 415..442 CDD:410632 4/26 (15%)
TM helix 7 450..475 CDD:410632 7/33 (21%)
adgre5b.3XP_005160275.1 EGF_CA 32..>62 CDD:214542
EGF_CA 72..103 CDD:429571
EGF_CA <121..152 CDD:214542
EGF_CA 154..188 CDD:214542
GPS 416..460 CDD:197639 5/43 (12%)
7tm_GPCRs 463..723 CDD:475119 63/289 (22%)
TM helix 1 466..490 CDD:410628 9/23 (39%)
TM helix 2 499..520 CDD:410628 6/23 (26%)
TM helix 3 530..552 CDD:410628 7/22 (32%)
TM helix 4 570..586 CDD:410628 2/15 (13%)
TM helix 5 605..628 CDD:410628 6/23 (26%)
TM helix 6 655..677 CDD:410628 6/23 (26%)
TM helix 7 682..707 CDD:410628 7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

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