DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl3 and Adgrf4

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001276428.1	Gene:	Adgrf4 / 78249	MGIID:	1925499	Length:	698	Species:	Mus musculus

Alignment Length:	615	Identity:	106/615 - (17%)
Similarity:	203/615 - (33%)	Gaps:	210/615 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AFLLLLLQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKVA 74
            ||::.||:|.::.:......|.|:..|...:.                              |||
Mouse   160 AFIVELLKNISSNLQTSGIHDNVNWKKMKNYG------------------------------KVA 194

  Fly    75 SHVRG--------------CACHLRPCIRFCCPQYQKMQKSKCYGD--------------MSEDE 111
            :|:.|              .:..|...:.....:.|...||:...|              .||..
Mouse   195 NHILGPTAISNWAFIANKNASSDLLESVNSFAKKLQIQGKSESIVDELFIQTKGSRISHSSSEHS 259

  Fly   112 LNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYF----------------------- 153
            |:...|..|.|            ||::|..::.:.....:.|
Mouse   260 LSLSVPRYNAT------------EDVLVVIEIPRQALQELSFNASQAIVVAFPTLGAILKEVHRP 312

  Fly   154 -LNHELPGNEFTL---FENG--SLLRHWDKVELSK--REYCVQHLSFK------DDSIRIAPHFC 204
             .|.:.|.::..|   ...|  .::..:||:..|:  ...||   |:.      |:|    |  |
Mouse   313 NTNLQKPIDDLILSLVLPEGLNEIILTFDKINKSQSTSSQCV---SWDPATGQWDES----P--C 368

  Fly   205 PLSSE----------HSRTWKTVAIVIS------------------------LICIILTISVY-- 233
            .:.|:          |::...:.:|::|                        ::|:::...|:
Mouse   369 TVMSDINSTVKCRCRHTKAVTSFSILMSSKPVKNTILNHITFIGLSISIFSLVLCLVIEAIVWSR 433

  Fly   234 LYVEKLRNLHGKCFICYLASLFLGYFFLVLNVW-----KYSSG------FCVTAGFLGYFSVIAA 287
            :.|.::..:...|.:....||      |..|||     .:|:.      :||...||.:|..::.
Mouse   434 VVVTEISYMRHVCIVNIAVSL------LTANVWFIIGSNFSANVQEDHKWCVAVTFLCHFFFLSL 492

  Fly   288 FFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNL-YAWGMALLLTAITYIADQVVKNEKLRPR 351
            |||:...:|.:   ..|......|.: ::|.::... ..:|..|::..||....:        |.
Mouse   493 FFWMLFKALLI---VYGILVVFRRMM-KSRMMAIGFAIGYGCPLVIAVITVTVTE--------PG 545

  Fly   352 VGVGKN--CWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNRLN 414
            .|..:.  ||:.......:..|..|.|.|:..|:.:.:..|..           ||:....   :
Mouse   546 EGYTRKDACWLNWNQTKALFAFAIPALAIVAVNLLVVLAVAIN-----------TQRPLIG---S 596

  Fly   415 SDKQTYALFLR-------LFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIFLLFV 472
            |..|..|:..|       |..::||:|...:.:.|...:..:...|.:.:.|   ||..|.|...
Mouse   597 SKSQDMAIVFRISKNVAILTPLLGLTWGFGLTTLLEGVHLVFHIIFALLNAF---QGFFILLFGT 658

  Fly   473 LRPSTLK-LLKERIKGGRDEAGASDEHISL 501
            :....:: .|:.|:...:.::.|: |.:||
Mouse   659 IMDHKIRDALRMRVSSLKGKSRAA-EKVSL 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	36/242 (15%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	49/266 (18%)
Adgrf4	NP_001276428.1	GPS	351..394	CDD:366827	9/51 (18%)
		7tm_GPCRs	402..669	CDD:391938	54/301 (18%)
		TM helix 1	405..429	CDD:341315	1/23 (4%)
		TM helix 2	444..465	CDD:341315	7/26 (27%)
		TM helix 3	479..501	CDD:341315	7/21 (33%)
		TM helix 4	522..538	CDD:341315	2/15 (13%)
		TM helix 5	560..583	CDD:341315	5/22 (23%)
		TM helix 6	606..631	CDD:341315	5/24 (21%)
		TM helix 7	636..661	CDD:341315	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810