DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and ADGRL4

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_071442.2	Gene:	ADGRL4 / 64123	HGNCID:	20822	Length:	690	Species:	Homo sapiens

Alignment Length:	477	Identity:	106/477 - (22%)
Similarity:	177/477 - (37%)	Gaps:	125/477 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DFFDTVDISKAPRFSNG----SYLYEGLLIPAHLTAEYDYKLLA------DDSKEKVASHVRGCA 81
            |:.:.....||...|||    :::|...:.|  |.:..|..||.      .:.:|:|.|.|...:
Human   277 DYINIFPKRKAAYDSNGNVAVAFVYYKSIGP--LLSSSDNFLLKPQNYDNSEEEERVISSVISVS 339

  Fly    82 CHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRH--------FKEDLI 138
            ....|      |...:::|                  :..|||...|..|:        :..| .
Human   340 MSSNP------PTLYELEK------------------ITFTLSHRKVTDRYRSLCAFWNYSPD-T 379

  Fly   139 VQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFKDDSI--RIAP 201
            :....:..||...|       .||.......:.|.|:..:..|.     ..:..||.:|  ||.
Human   380 MNGSWSSEGCELTY-------SNETHTSCRCNHLTHFAILMSSG-----PSIGIKDYNILTRIT- 431

  Fly   202 HFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRN----LHGKCFICYLASLFLG--YFF 260
                          .:.|:|||||:.:.|..:.:..::::    :| |...|   ||||.  .|.
Human   432 --------------QLGIIISLICLAICIFTFWFFSEIQSTRTTIH-KNLCC---SLFLAELVFL 478

  Fly   261 LVLNVWKYSSGFC-VTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLY 324
            :.:|. ..:..|| :.||.|.|| .:|||.|:.:..:.|:....|       .:....||..|.|
Human   479 VGINT-NTNKLFCSIIAGLLHYF-FLAAFAWMCIEGIHLYLIVVG-------VIYNKGFLHKNFY 534

  Fly   325 AWGMALLLTAITYIADQVVK--NEKLRPR-VGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMF 386
            .:|         |::..||.  :..|..| .|..|.||:.| :...:..|.||..|||:.|:..|
Human   535 IFG---------YLSPAVVVGFSAALGYRYYGTTKVCWLST-ENNFIWSFIGPACLIILVNLLAF 589

  Fly   387 VLTAFRIMK----VKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQ 447
            .:..:::.:    :|.|...|...:......          |.|..::|.:|...:: .::..:.
Human   590 GVIIYKVFRHTAGLKPEVSCFENIRSCARGA----------LALLFLLGTTWIFGVL-HVVHASV 643

  Fly   448 AWAKAFMVADYFNWSQGTVIFL 469
            ..|..|.|::.|   ||..|||
Human   644 VTAYLFTVSNAF---QGMFIFL 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	38/196 (19%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	59/233 (25%)
ADGRL4	NP_071442.2	EGF_CA	58..>91	CDD:284955
		GAIN	139..330	CDD:293098	12/54 (22%)
		GPS	368..412	CDD:280071	8/51 (16%)
		7tm_4	424..660	CDD:304433	68/287 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810