DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and ADGRG6

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006715579.1	Gene:	ADGRG6 / 57211	HGNCID:	13841	Length:	1251	Species:	Homo sapiens

Alignment Length:	361	Identity:	81/361 - (22%)
Similarity:	148/361 - (40%)	Gaps:	79/361 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WDKVELSKREY--------CVQHL-SFKDDSIRIAPHF--------CPLSSEH--SRTWKTVAIV 220
            ||   |:|.:.        ||.|. |...:::.:..||        .|.|:..  :|..|.:..:
Human   807 WD---LNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSASQLDARNTKVLTFI 868

  Fly   221 ------ISLICIILTISVYLYVEKLRNLHGKCFICYL--ASLFLGYFFLVLNVWKYS---SGFCV 274
                  ||.|....|:..|:..||||..:....:..|  |.|||...|| |:.|..|   .|.|:
Human   869 SYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFL-LDGWITSFNVDGLCI 932

  Fly   275 TAGFLGYFSVIAAFFWLSVISLTLWNSF-SGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYI 338
            ....|.:|.::|.|.|:.:.::.::.:. ...::::.|::     |.:.:..||:..|:.::. :
Human   933 AVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYI-----LKFCIIGWGLPALVVSVV-L 991

  Fly   339 ADQVVKNEKLRPRVGVGKN-----CWIYTGDMTVMIY-----FYGPMLLIIVFNITMFVLTAFRI 393
            |.:  .|.::..:...||.     |||..   .|:.|     ::|.|..:   ||.||::...:|
Human   992 ASR--NNNEVYGKESYGKEKGDEFCWIQD---PVIFYVTCAGYFGVMFFL---NIAMFIVVMVQI 1048

  Fly   394 MKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAK---AFM- 454
            .....:..|.|.:::....|.|       .:.|..::|::|.....        ||..   .||
Human  1049 CGRNGKRSNRTLREEVLRNLRS-------VVSLTFLLGMTWGFAFF--------AWGPLNIPFMY 1098

  Fly   455 VADYFNWSQGTVIFLLF-VLRPSTLKLLKERIKGGR 489
            :...||..||..||:.. .::.:..|..::.:..||
Human  1099 LFSIFNSLQGLFIFIFHCAMKENVQKQWRQHLCCGR 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	10/45 (22%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	54/241 (22%)
ADGRG6	XP_006715579.1	CUB	44..147	CDD:238001
		LamG	154..338	CDD:304605
		GPS	802..847	CDD:280071	10/42 (24%)
		7tm_4	864..1111	CDD:304433	62/276 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810