Protein Alignment mthl3 and Adgrf2

DIOPT Version :9

• Sequence 1: NP_001286526.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: XP_017173054.1
• Gene: Adgrf2 / 435529
• MGIID: 2182728
• Length: 673
• Species: Mus musculus
• Alignment Length: 448
• Identity: 101/448 - (22%)
• Similarity: 179/448 - (39%)
• Gaps: 99/448 - (22%)

  Fly   107 MSEDELNKHDPFVNV------TLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTL 165
            :|.:||.|......|      ||  |:::.....|::.|.      |......|..||. |...:
Mouse   260 LSPEELQKVPSAFQVISIAFPTL--GAILEASLLENVTVN------GLVLSVILPEELK-NISLI 315

  Fly   166 FEN--------------GSLLRHWD-----KVELSKRE---YCVQHLSFKDDSIRIAPHF--CPL 206
            ||.              .||...||     .::.:.|:   .|..:..:...||.::|:.  .|:
Mouse   316 FEKIRKSGERKSQCVGWHSLESRWDWRACKTIQENSRQAVCRCRPNKLYTSFSILMSPNTLESPV 380

  Fly   207 SSEHSRTWKTVAIVISLICIILTISVYLYVEK-----LRNLHGKCFICYLASLFLGYFFLVLNVW 266
            .:..:.....::|...:||:.:.:.|:..|.|     ||:|   |.....|:|      |:.:.|
Mouse   381 LTYITYIGLGISICSLIICLAIEVLVWSQVTKTEISYLRHL---CIANIAATL------LMADAW 436

  Fly   267 KYSSGF----------CVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRF--LPQNRFL 319
            ...:.|          ||.|.|..:|..::.|||:...:|.:....      |..|  ||::..:
Mouse   437 FIVASFLSGPVLHHNGCVAATFFVHFFYLSVFFWMLAKALLILYGI------LIVFHTLPKSCLV 495

  Fly   320 SYNLYA--WGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMT-VMIYFYGPMLLIIVF 381
            : :|::  :|..|::..||....:..|. .|||..     ||: ..||| .::.|..|.|.|:|.
Mouse   496 A-SLFSVGYGCPLVIAIITLAVTEPGKG-YLRPEA-----CWL-NWDMTKALLAFVVPALAIVVV 552

  Fly   382 NITMFVLTAFRIMKVKKEA--QNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLS 444
            |:   :.....|:|.::.|  .:..|:.:...|:..:      ...|..::||:|...|.:.:..
Mouse   553 NL---ITVTMVIIKTQRAAIGSSMFQEVRAIVRICKN------IAILTPLLGLTWGFGIATVING 608

  Fly   445 KNQAWAKAFMVADYFNWSQGTVIFLLF--VLRPSTLKLLKERIKGGRDEAGASDEHIS 500
            .:.|:   .::....|..||..| |||  :|.|...:.||.||...:..:..|::..|
Mouse   609 HSLAF---HIIFSLLNALQGFFI-LLFGTILDPKIREALKSRITSAKWISRVSEDFSS 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	26/126 (21%)
		7tm_4	216..436	CDD:304433	57/241 (24%)
Adgrf2	XP_017173054.1	GPS	326..373	CDD:383024	8/46 (17%)
		7tmB2_GPR111_115	378..644	CDD:320660	69/301 (23%)
		TM helix 1	381..405	CDD:320660	3/23 (13%)
		TM helix 2	420..441	CDD:320660	6/29 (21%)
		TM helix 3	454..476	CDD:320660	7/21 (33%)
		TM helix 4	497..513	CDD:320660	3/15 (20%)
		TM helix 5	535..558	CDD:320660	8/25 (32%)
		TM helix 6	581..606	CDD:320660	6/30 (20%)
		TM helix 7	611..636	CDD:320660	8/28 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810