DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl3 and mthl6

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_788473.1	Gene:	mthl6 / 38839	FlyBaseID:	FBgn0035789	Length:	480	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	200/514 - (38%)
Similarity:	303/514 - (58%)	Gaps:	68/514 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AFLLLLLQNSNAE--IPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEK 72
            |.:|:.:.:|.:|  |||||:|||||||..|:. |.||.||.|:||||||..|.::.|||.|:|.
  Fly     7 AIILVFVISSQSEAVIPGCDYFDTVDISHIPKL-NDSYAYEELIIPAHLTGLYTFRQLADGSQEP 70

  Fly    73 VASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDL 137
            |.||:|.|.|.|:||||||||:.:.|..|:|...::|: |.:.:|::.:||.||::.:.:...|:
  Fly    71 VKSHLRACICKLKPCIRFCCPRNKMMPNSRCSDGLTEN-LKRINPYLKITLEDGTIGKYYLLTDM 134

  Fly   138 IVQSDLAKPGCPRMYFLNHE---------LPGNEFTLFENGSLL----RHWDKVELSKREYCVQH 189
            ||              |.:|         :..:::.|:||||.:    .:|   .|||:.||: |
  Fly   135 IV--------------LRYEFRYCEKVVSVQEDQYKLYENGSFMIKPDVNW---TLSKQWYCL-H 181

  Fly   190 LSFKD-DSIRIAPH-FCPLSSEHSRTWKTVAIV-----ISLICIILTISVYLYVEKLRNLHGKCF 247
            ...:| :||.|..| :.|         |::..|     ||::..||||:||||::|||||.||||
  Fly   182 PRLEDPNSIWILEHVYIP---------KSMPAVPQVGTISMVGCILTIAVYLYIKKLRNLLGKCF 237

  Fly   248 ICYLASLFLGYFFLV---LNVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWL 309
            |||:...|:.|....   ||:|   :..|..||:..||..:|:.|||||:|..:|.    |...:
  Fly   238 ICYVFCKFVQYLIWAGGDLNLW---NNICSLAGYTNYFFALASHFWLSVMSHQIWK----NLRLI 295

  Fly   310 NRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKN--EKLRPRVGVG-KNCWIYTGDMTVMIYF 371
            ||......||.||:|.||...::|||||:.|...::  :||....||| ..|||.|.|.:.|||.
  Fly   296 NRDERSYHFLIYNIYGWGTPAIMTAITYLVDWAWEDRPDKLNWIPGVGLYRCWINTYDWSAMIYL 360

  Fly   372 YGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSL 436
            |||||::.:||:..|:||...|||:|...::.||||:...: |:|   :.|:|||.::||::...
  Fly   361 YGPMLILSLFNVVTFILTVNHIMKIKSSVKSSTQQQRKCIQ-NND---FLLYLRLSVMMGVTGIS 421

  Fly   437 EIISFLLSKNQAWAKAFMVADYFNWSQGTVIFLLFVLRPSTLKLLKERIKGGRDEAGAS 495
            |:|::.:.:::.|.:...|.::|:...|.|:|:||:|:.||.:::.|||.|.|.:..||
  Fly   422 EVITYFVKRHKFWRQVLRVPNFFHLGSGIVVFVLFILKRSTFQMIMERISGPRRQQPAS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	75/192 (39%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	96/230 (42%)
mthl6	NP_788473.1	Mth_Ecto	25..197	CDD:119403	75/191 (39%)
mthl6	NP_788473.1	7tm_4	211..398	CDD:304433	87/193 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980