DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and Adgrg5

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_001139444.1 Gene:Adgrg5 / 382045 MGIID:2685955 Length:524 Species:Mus musculus


Alignment Length:288 Identity:58/288 - (20%)
Similarity:115/288 - (39%) Gaps:71/288 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 VAIVISLICIILTISVYLYVEKL--------RNLHGKCFICYLASLFLGYFFLV---LNVWKYSS 270
            |...||::..:|||.:|....|.        .||:|       :.|.|...||:   :.:.....
Mouse   250 VGCSISIVASLLTILLYAQSRKQSDSTTRIHMNLNG-------SVLLLNVTFLLSSQMTLPTMPR 307

  Fly   271 GFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGN--SSWLNRFLPQNRFLSYNLYAWGMALLLT 333
            ..|.....:.:::::::..|:::....|: .|.|.  ::::.|:|     |...:..||...||.
Mouse   308 PVCKVLAAVLHYALLSSLTWMAIEGFNLY-LFLGRVYNAYIRRYL-----LKLCMLGWGFPALLV 366

  Fly   334 AITYIADQVVKNEKLRPRV---------GVG----KNCWIYTGDM-TVMIYFYG---PMLLIIVF 381
            .:..    ::|:....|.|         |.|    ..|||.:..: ::::..||   .:..::|.
Mouse   367 LLLL----MIKSSVYGPCVTSLSKSQENGTGFQNVSMCWIRSPMVHSILVMGYGGFTSLFNLVVL 427

  Fly   382 NITMFVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIIS---FLL 443
            ...:::|...|   .:::|.:....:.|           |:.|.|.:::|.:|:|...|   |||
Mouse   428 AWALWILCRLR---AREKALSPWAYRDT-----------AMVLGLTVLLGTTWTLAFFSFGVFLL 478

  Fly   444 SKNQAWAKAFMVADYFNWSQGTVIFLLF 471
            .:       ..:...||...|..:||.|
Mouse   479 PQ-------LFLFTIFNSLYGFFLFLWF 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145
7tm_4 216..436 CDD:304433 47/248 (19%)
Adgrg5NP_001139444.1 GPS 184..228 CDD:366827
7tm_GPCRs 242..514 CDD:391938 58/288 (20%)
TM helix 1 244..268 CDD:341315 7/17 (41%)
TM helix 2 277..298 CDD:341315 7/27 (26%)
TM helix 3 311..333 CDD:341315 1/21 (5%)
TM helix 4 353..369 CDD:341315 4/15 (27%)
TM helix 5 405..428 CDD:341315 3/22 (14%)
TM helix 6 449..474 CDD:341315 8/35 (23%)
TM helix 7 478..503 CDD:341315 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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