DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgrf3

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006535799.1	Gene:	Adgrf3 / 381628	MGIID:	2685887	Length:	1059	Species:	Mus musculus

Alignment Length:	412	Identity:	95/412 - (23%)
Similarity:	149/412 - (36%)	Gaps:	130/412 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 GNEFTLFE--------NGSLLRH---WDKVELSKR-----EYCVQHLSFKDDSIRIAPH---FCP 205
            |..||..|        ||:|  |   ||......:     |.|..|.:....:..|..|   |..
Mouse   615 GQAFTQAEVIMDYEDMNGTL--HCVFWDHRVFQGQGGWSDEGCEVHAANASITQCICQHLTAFSI 677

  Fly   206 LSSEH-----------SRTWKTVAIVISLICIILTISVYLYVEKLRN-----LHGKCF---ICYL 251
            |.|:|           |:.....:::..|:|:.:...|:..|  :||     .|...|   ||.|
Mouse   678 LMSQHTVPENPTLDLLSQVGTGASVLALLVCLAIYGLVWRVV--VRNKVAFFRHTTLFNMVICLL 740

  Fly   252 A--SLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWN-------------- 300
            .  :.|||..||...   |.|..|:...||.:|..:|.|||:...:|.|.:
Mouse   741 VADTCFLGSPFLPSG---YHSLICLVTAFLCHFFYLATFFWMLAQALVLAHQLLFVFHQLSKHVV 802

  Fly   301 -------------SFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRV 352
                         .|:|.:  |..:|||.::|      |
Mouse   803 LSLMVMLGYLCPLGFAGVT--LGLYLPQRKYL------W-------------------------- 833

  Fly   353 GVGKNCWIYTGDMTVMIY-FYGPMLLIIVFNITMFVLTAFRIMKVK-KEAQNFTQQQKTTNRLNS 415
             .|| |::..|.  ||:| |..|:|.|:..|..:.|:...::::.. .|.....::|.....|.:
Mouse   834 -EGK-CFLNGGG--VMLYSFSEPVLAIVGVNGLVLVIAVLKLLRPSLSEGPTVEKRQALVGVLKA 894

  Fly   416 DKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIFLLFVLR-PSTLK 479
                   .|.|..|.||:|.|.:.: |...:.....||.:   .|..||..|.:...|. ...|:
Mouse   895 -------LLILTPIFGLTWGLGVAT-LFDGSIVSHYAFSI---LNSLQGVFILVFGCLTDKKVLE 948

  Fly   480 LLKERIKGGRDEAGASDEHISL 501
            .|::|::|.|    :|:..||:
Mouse   949 ALRKRLRGSR----SSNSAISM 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	15/62 (24%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	58/258 (22%)
Adgrf3	XP_006535799.1	HRM	352..398	CDD:367186
		GPS	635..678	CDD:366827	9/42 (21%)
		7tm_GPCRs	688..954	CDD:391938	70/319 (22%)
		TM helix 1	689..714	CDD:341315	3/24 (13%)
		TM helix 2	729..751	CDD:341315	8/21 (38%)
		TM helix 3	762..789	CDD:341315	9/26 (35%)
		TM helix 4	803..823	CDD:341315	2/21 (10%)
		TM helix 5	842..871	CDD:341315	10/30 (33%)
		TM helix 6	887..914	CDD:341315	8/34 (24%)
		TM helix 7	918..943	CDD:341315	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810