DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl3 and mth

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_728521.1	Gene:	mth / 38058	FlyBaseID:	FBgn0023000	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	287/481 - (59%)
Similarity:	367/481 - (76%)	Gaps:	6/481 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SFTAFLLLLLQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKE 71
            |....::|::|.|.|:|..||:|||||||.|.:..|||||:||||:||.||.|||:::|.||||:
  Fly    10 STVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQ 74

  Fly    72 KVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKED 136
            |||.|:|||.|.|:||:|||||....|....||.:||::||.:.|||:||||.||||.|||||.:
  Fly    75 KVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNE 139

  Fly   137 LIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSFKD---DSIR 198
            ||||.||..| |..|::|::....:::||||||:..||:|:|.|.|||||:|||:|.|   .|||
  Fly   140 LIVQWDLPMP-CDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIR 203

  Fly   199 IAPHFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVL 263
            ||||.|.:..  |.|.:||.::.||||::|||:|||:|:||:||||||||||:..||:||.||:|
  Fly   204 IAPHNCLIVP--SITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLL 266

  Fly   264 NVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGM 328
            ::|:.|..||..|||||||.|:|||||||||||.|||:|.|:|...||||.::|||:||.|||||
  Fly   267 DLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGM 331

  Fly   329 ALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRI 393
            |::||.||.:||.:|:|:...||||...:|||||...:.|:||||||:.:|.||||||:|||.||
  Fly   332 AVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRI 396

  Fly   394 MKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADY 458
            :.|||:.|||..:|:...:||||||||..||||||||||||||||.|:....||.||..|:||||
  Fly   397 LGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADY 461

  Fly   459 FNWSQGTVIFLLFVLRPSTLKLLKER 484
            .|||||.:||:||||:.||.:||:||
  Fly   462 LNWSQGIIIFILFVLKRSTWRLLQER 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	108/180 (60%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	139/219 (63%)
mth	NP_728521.1	Methuselah_N	29..209	CDD:284145	108/180 (60%)
mth	NP_728521.1	7tm_4	219..416	CDD:304433	119/196 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449689
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25921
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	1	1.000	-	-		mtm9601
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.910