DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and mthl10

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	184/507 - (36%)
Similarity:	281/507 - (55%)	Gaps:	32/507 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKVASHVRGCACHLRPCIRF 90
            |:|:|||:::....|.||||.|.|.::||.|...|||...:...:.:|..|||||.|..:.|:..
  Fly    56 CNFYDTVNLTGHRLFPNGSYDYYGTIVPAELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNI 120

  Fly    91 CCP--QYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYF 153
            |||  |....:...|..|.|::......|.:|:|..:.|.:..:......:||  .:| ||:|:.
  Fly   121 CCPWRQVFNSEVDGCIIDHSDNRTWPDPPMLNITFRNESTILVNMFTQFAIQS--FRP-CPKMFS 182

  Fly   154 LNHELPG-NEFTLFENGSLLRHWDKVELSKREYCV--QHLSFKDDSIRIAPHFCPLSSEHSRTWK 215
            |..|... :::.||||||:||..||:.:.|.|:|:  .:::..|....|.|..|.:..:|| |.|
  Fly   183 LQPETNNWDDYLLFENGSMLRVDDKLLIRKNEFCMVPTYVNESDMFYTIHPANCDMQDDHS-TVK 246

  Fly   216 TV---AIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKY---SSGF-C 273
            .:   |::.|:..::|||:|||.:.:|||.|||..:|||..|.:||..|.. |..|   ::|. |
  Fly   247 IINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCY-VQLYQVDATGVTC 310

  Fly   274 VTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYI 338
            ...|:..||..:.|:.||||||..||::|.|... :|||..:.|||.|:||:||:||:..|.||.
  Fly   311 KVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRG-INRFQEKKRFLFYSLYSWGIALVFLAFTYC 374

  Fly   339 ADQVVK-NEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQN 402
            |.|:.. ...|:|.:|.|..||:...:...|||||||:|.|:|.|..||::||.:|..|::|...
  Fly   375 AQQLTNLPANLKPGIGDGVYCWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMAR 439

  Fly   403 FTQQQKTTNRLNSDKQ----------TYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVAD 457
            ....:.:|..|.::|.          .:.||||||:|||::|..|:||:.:..::.|:|.|.::|
  Fly   440 IIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISD 504

  Fly   458 YFNWSQGTVIFLLFVLRPSTLKLLKERIKGGRDEAGASDEHISLQNTKIDPS 509
            ..|..||.:||:|||::.....|:..|....||   .|::..|..:||...|
  Fly   505 LANAMQGFLIFMLFVMKKKVKHLITNRCSSVRD---GSNQRQSQYSTKTTSS 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	61/182 (34%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	94/237 (40%)
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	61/182 (34%)
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	106/271 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	1	1.000	-	-		mtm9601
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.070