DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgre5

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001012164.1	Gene:	Adgre5 / 361383	RGDID:	1305595	Length:	825	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	62/284 - (21%)
Similarity:	114/284 - (40%)	Gaps:	55/284 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 VAIVISLICIILTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWKYSSGF---CV 274
            |.:::||:|::|.|..:|.|:.:::    :|....||    ||||....::.|.......   |.
  Rat   543 VGLLLSLVCLLLCILTFLLVKPIQSSRTMVHLHLCIC----LFLGSVIFLVGVENEGGEVGLRCR 603

  Fly   275 TAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAW-------GMALLL 332
            ....|.:|..:|||.|:::..:.|:            ||....|....|..|       |:.||:
  Rat   604 LVAMLLHFCFLAAFCWMALEGVELY------------FLVVRVFQGQGLSTWHRCLVGYGVPLLI 656

  Fly   333 TAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVK 397
            .||:..|..        ...|....||:.......:..|.||:..||..|..:||:|.:::.|
  Rat   657 VAISAAARM--------DGYGHATYCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVITVWKLTK-- 711

  Fly   398 KEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWS 462
                .|::......:|...:......:...:::|.:|...:  ||.:.:..|..  .:....|..
  Rat   712 ----KFSEINPNMKKLRKARVLTITAIAQLLVLGCTWGFGL--FLFNPHSTWLS--YIFTLLNCL 768

  Fly   463 QGTVIFLLFVLRPSTLKLLKERIK 486
            ||..:::       ||.||.::::
  Rat   769 QGLFLYV-------TLCLLNKKVR 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	52/232 (22%)
Adgre5	NP_001012164.1	EGF_CA	69..>101	CDD:214542
		EGF_CA	171..218	CDD:284955
		EGF_CA	220..265	CDD:284955
		GPS	487..526	CDD:280071
		7tm_2	534..773	CDD:278432	58/263 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810