DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl3 and Adgrl1

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_030099484.1 Gene:Adgrl1 / 330814 MGIID:1929461 Length:1543 Species:Mus musculus


Alignment Length:344 Identity:83/344 - (24%)
Similarity:136/344 - (39%) Gaps:73/344 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 NHELPGNEFTLFENGSLLRHWDK-----VELSK-REYCV-QHLSFKDDSIRIAPHFCPLSSEHS- 211
            ||......|..:...|:|.:|..     ||.:| ...|. .||:          :|..|.:... 
Mouse   867 NHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLT----------NFAVLMAHREI 921

  Fly   212 ------------RTWKTVAIVISLICIILTISVYLYVEKL---RNLHGK--CFICYLASLFLGYF 259
                        .||  |.|||||:|:.:.||.:.::..|   ||...|  |...:||.|.   |
Mouse   922 YQGRINELLLSVITW--VGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELL---F 981

  Fly   260 FLVLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSV----ISLTLWNSFSGNSSWLNRFLPQNRFLS 320
            .:.::..:|.....:.||.|.|| .:|||.||.:    :.|.|...|....|         |...
Mouse   982 LVGIDKTQYEVACPIFAGLLHYF-FLAAFSWLCLEGVHLYLLLVEVFESEYS---------RTKY 1036

  Fly   321 YNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITM 385
            |.|..:....|:..|....|.        ...|..|.||:.. |...:..|.||:..:||.|:..
Mouse  1037 YYLGGYCFPALVVGIAAAIDY--------RSYGTEKACWLRV-DNYFIWSFIGPVSFVIVVNLVF 1092

  Fly   386 FVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWA 450
            .::|..::::      :.:..:..::||::.|......:.|..::||:|:..:: |:..::...|
Mouse  1093 LMVTLHKMIR------SSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLL-FINKESVVMA 1150

  Fly   451 KAFMVADYFNWSQGTVIFL 469
            ..|..   ||..||..||:
Mouse  1151 YLFTT---FNAFQGVFIFV 1166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145 12/55 (22%)
7tm_4 216..436 CDD:304433 58/228 (25%)
Adgrl1XP_030099484.1 OLF 214..470 CDD:383019
PLN02550 491..>573 CDD:178165
HormR 548..611 CDD:214468
GAIN 621..845 CDD:374574
GPS 869..921 CDD:197639 12/61 (20%)
7tmB2_Latrophilin-1 928..1185 CDD:320673 69/273 (25%)
TM helix 1 931..955 CDD:320673 11/25 (44%)
TM helix 2 964..985 CDD:320673 7/23 (30%)
TM helix 3 995..1017 CDD:320673 10/22 (45%)
TM helix 4 1036..1052 CDD:320673 3/15 (20%)
TM helix 5 1071..1094 CDD:320673 7/22 (32%)
TM helix 6 1118..1143 CDD:320673 6/25 (24%)
TM helix 7 1147..1172 CDD:320673 8/23 (35%)
Latrophilin 1185..1543 CDD:367050
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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