DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgrl3

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_011247763.1	Gene:	Adgrl3 / 319387	MGIID:	2441950	Length:	1586	Species:	Mus musculus

Alignment Length:	279	Identity:	63/279 - (22%)
Similarity:	112/279 - (40%)	Gaps:	60/279 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 TWKTVAIVISLICIILTISVYLYVEKLRN----LH-GKCFICYLASLFLGYFFLVLNVWKYSSGF 272
            ||  |.|::||:|:::.|..:.:...|::    :| ..|...::|.|.   |.:.:|........
Mouse   949 TW--VGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELL---FLIGINRTDQPIAC 1008

  Fly   273 CVTAGFLGYFSVIAAFFWLSVISLTLW----NSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLT 333
            .|.|..|.:| .:|||.|:.:..:.|:    ..|....|         |...:.|..:||..|:.
Mouse  1009 AVFAALLHFF-FLAAFTWMFLEGVQLYIMLVEVFESEHS---------RRKYFYLVGYGMPALIV 1063

  Fly   334 AITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIY-FYGPMLLIIVFNITMFVLTAFRIMK-- 395
            |::...|.        ...|..|.||:...  |..|: |.||..|||:.|:....:..:::..
Mouse  1064 AVSAAVDY--------RSYGTDKVCWLRLD--TYFIWSFIGPATLIIMLNVIFLGIALYKMFHHT 1118

  Fly   396 --VKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFII--------MGLSWSLEIISFLLSKNQAWA 450
              :|.|:..........||         .|::.::|        :||:|:..:: ::.......|
Mouse  1119 AILKPESGCLDNINYEDNR---------PFIKSWVIGAIALLCLLGLTWAFGLM-YINESTVIMA 1173

  Fly   451 KAFMVADYFNWSQGTVIFL 469
            ..|.:   ||..||..||:
Mouse  1174 YLFTI---FNSLQGMFIFI 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	53/241 (22%)
Adgrl3	XP_011247763.1	Gal_Lectin	111..191	CDD:366935
		OLF	205..461	CDD:128580
		HormR	563..627	CDD:214468
		GAIN	636..856	CDD:374574
		GPS	882..934	CDD:197639
		7tmB2_Latrophilin-3	942..1208	CDD:320671	63/279 (23%)
		TM helix 1	945..969	CDD:320671	8/21 (38%)
		TM helix 2	978..999	CDD:320671	5/23 (22%)
		TM helix 3	1009..1031	CDD:320671	8/22 (36%)
		TM helix 4	1050..1066	CDD:320671	5/15 (33%)
		TM helix 5	1085..1108	CDD:320671	9/24 (38%)
		TM helix 6	1141..1166	CDD:320671	4/25 (16%)
		TM helix 7	1170..1195	CDD:320671	8/23 (35%)
		Latrophilin	1208..1586	CDD:367050
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810