DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgre1

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001007558.1	Gene:	Adgre1 / 316137	RGDID:	1359214	Length:	932	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	99/425 - (23%)
Similarity:	155/425 - (36%)	Gaps:	116/425 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 GSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHL 190
            |..|....|||.         ..|.:|.|.|..|..:                  |:|..||...
  Rat   563 GGTVTGERKEDF---------SKPIVYTLQHIQPKQK------------------SERSICVSWN 600

  Fly   191 SFKDDSIRIAPHFCPLSSEHSRTWKT-----------------------------VAIVISLICI 226
            :..:|. |..|..|. :.|.|.|...                             |..||||:|:
  Rat   601 TDVEDG-RWTPSGCE-TVEASETHTVCSCNRMTNLAIIMASGELTMEFSLYIISYVGTVISLVCL 663

  Fly   227 ILTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWK--YSSGFCVTAGFLGYFSVI 285
            .|.|:.:|....::|    ||....:|    |||.....:..:.|  ..:...:.||||.|. .:
  Rat   664 ALAIATFLLFRAVQNHNTYLHLHLCVC----LFLAKILFLTGIDKTDNQTACAIIAGFLHYL-FL 723

  Fly   286 AAFFWLSVISLTLWNSFSGNSSWLNRFLPQN-RFLSYNLYAWGMALLLTAITYIADQVVKNEKLR 349
            |.|||:.|.::.|: ....|...:|.|..:| :.|....:.:|:.:::         |:.:..:.
  Rat   724 ACFFWMLVEAVMLF-LMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVVV---------VIISATVH 778

  Fly   350 P-RVGVGKNCWIYTGDMTVMIY-FYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNR 412
            | ..|:...||:.|  .|..|: |.||:.:||..|..:...|.:.:.:......:...:.|.|..
  Rat   779 PWGYGMHNRCWLNT--ETGFIWSFLGPVCMIITINSALLAWTLWVLRQKLCSVNSEVSKLKDTRL 841

  Fly   413 LNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYF---NWSQGTVIFLLFVLR 474
            |     |:....::| |:|.||.|.|.       |....|.::|..|   |..||..|||:..
  Rat   842 L-----TFKAIAQIF-ILGCSWVLGIF-------QIGPLASIMAYLFTTINSLQGAFIFLIHC-- 891

  Fly   475 PSTLKLLKERIKGGRDEAGASDEHISLQNTKIDPS 509
                 ||..:::         ||:..|...|.|.|
  Rat   892 -----LLNRQVR---------DEYRKLLTRKTDLS 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	17/77 (22%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	58/257 (23%)
Adgre1	NP_001007558.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..>109	CDD:214542
		EGF_CA	133..172	CDD:214542
		EGF_CA	173..>203	CDD:214542
		EGF_CA	222..255	CDD:214542
		cEGF	245..275	CDD:289433
		EGF_CA	272..>301	CDD:214542
		EGF_CA	319..359	CDD:284955
		Cell attachment site. /evidence=ECO:0000255	507..509
		GPS	592..641	CDD:197639	10/50 (20%)
		7tm_2	646..886	CDD:278432	67/269 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810