DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl3 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_218313.7	Gene:	Adgrg6 / 308376	RGDID:	1308551	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	77/342 - (22%)
Similarity:	142/342 - (41%)	Gaps:	68/342 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 CVQHL-SFKDDSIRIAPHF--------CPLSSEH--SRTWKTVAIV------ISLICIILTISVY 233
            ||.|. |...::|.:..||        .|.|:..  .|..|.:..:      ||.|....|:..|
  Rat   820 CVAHSDSDAGETICLCNHFTHFGVLMDLPRSASQIDGRNTKVLTFITYIGCGISAIFSAATLLTY 884

  Fly   234 LYVEKLRNLHGKCFICYLAS--LFLGYFFLVLNVWKYS---SGFCVTAGFLGYFSVIAAFFWLSV 293
            :..||||..:....:..|:|  |||...|| |:.|..|   :|.|.....|.:|.::|.|.|:.:
  Rat   885 VAFEKLRRDYPSKILMNLSSALLFLNLIFL-LDGWITSFGVAGLCTAVAALLHFFLLATFTWMGL 948

  Fly   294 ISLTLWNSF-SGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKN 357
            .::.::.:. ...:::::|::     |.:.:..||:..|:.:|..::.   |..::..:...||:
  Rat   949 EAIHMYIALVKVFNTYIHRYI-----LKFCIIGWGLPALVVSIILVSR---KQNEVYGKESYGKD 1005

  Fly   358 -----CWIYTGDMTVMIY-----FYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNR 412
                 |||..   .|:.|     ::|.|..:   |:.||::...:|.....:..|.|.:::....
  Rat  1006 QDDEFCWIQD---PVVFYVSCAGYFGIMFFL---NVAMFIVVMVQICGRNGKRSNRTLREEVLRN 1064

  Fly   413 LNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAK---AFM-VADYFNWSQGTVIFLLF-V 472
            |.|       .:.|..::|::|.....        ||..   .|| :...||..||..||:.. .
  Rat  1065 LRS-------VVSLTFLLGMTWGFAFF--------AWGPLNIPFMYLFSIFNSLQGLFIFIFHCA 1114

  Fly   473 LRPSTLKLLKERIKGGR 489
            ::.:..|..:..:..||
  Rat  1115 MKENVQKQWRRHLCCGR 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	7/26 (27%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	53/241 (22%)
Adgrg6	XP_218313.7	CUB	38..146	CDD:238001
		LamG	178..337	CDD:304605
		GPS	799..844	CDD:280071	7/23 (30%)
		7tm_4	861..1108	CDD:304433	61/276 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810