DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgrg7

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001100568.1	Gene:	Adgrg7 / 304014	RGDID:	1307217	Length:	785	Species:	Rattus norvegicus

Alignment Length:	222	Identity:	48/222 - (21%)
Similarity:	97/222 - (43%)	Gaps:	34/222 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 SVIAAFFWLSVISLTLWNSFSGNSSWL-----NRFLPQNRFLSYNLYAWGMALLLTAITYIADQV 342
            :.|||.....::....||..|....:.     .:.||::..:..:|..||:..::..:|......
  Rat   523 TAIAALLHYFLLGTFTWNGLSATQLYFLLIRTMKPLPRHFIVIISLVGWGVPAIIVGVTIGIIYA 587

  Fly   343 VKNEKLRPRVGVGKN--CWI---YTGDMT---VMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKE 399
            :...|....:...:.  ||:   ...|..   ::..|..|:.:|::.||.:||:...:::  .|.
  Rat   588 LSGNKSYWELDYRQEEICWLAVPKNNDFARSPLLWSFIMPVTIILITNIAIFVIITVKVL--WKN 650

  Fly   400 AQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADY----FN 460
            .||.|    :|.:::|.|:..:. |.:.::.|::|   |.::.:..|....:  :|..|    ||
  Rat   651 NQNLT----STKKVSSLKKVLST-LSIAVVFGVTW---IFAYAMLINNDDIR--IVFSYIFCLFN 705

  Fly   461 WSQGTVIFLLFVLRPSTL-----KLLK 482
            .:||..||:|:.:|....     |:||
  Rat   706 TTQGLQIFILYTVRTKVFQNEASKILK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	33/165 (20%)
Adgrg7	NP_001100568.1	GPS	378..418	CDD:396408
		7tmB2_GPR128	428..727	CDD:320385	45/215 (21%)
		TM helix 1	431..455	CDD:320385
		TM helix 2	465..486	CDD:320385
		TM helix 3	523..545	CDD:320385	6/21 (29%)
		TM helix 4	565..581	CDD:320385	3/15 (20%)
		TM helix 5	617..640	CDD:320385	5/22 (23%)
		TM helix 6	666..688	CDD:320385	4/25 (16%)
		TM helix 7	695..720	CDD:320385	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810