DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgrf2

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_017452241.2	Gene:	Adgrf2 / 301269	RGDID:	1306718	Length:	654	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	108/538 - (20%)
Similarity:	201/538 - (37%)	Gaps:	145/538 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQNSNAEIPGCDFFDTVDISKAPRFSNG-----SYLY---EGLLIPAH-LTAEYDYKLLADDSKE 71
            :|:.|:   .|....:::...:..|..|     |:::   .|.::|.: |...:.:.:..:|:.:
  Rat   195 IQDRNS---SCVLLQSINSFASNLFMKGHLINISHVFIHTLGTVVPRNSLGKNFTFSMRVNDTSD 256

  Fly    72 KVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNV------TLSDGSVVR 130
            ||...:.                            ::.:||.|......|      ||  |:::.
  Rat   257 KVTGRIL----------------------------LTTEELQKVPSAFQVISIAFPTL--GAILE 291

  Fly   131 RHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFEN--------------GSLLRHWDK---- 177
            ....|::.|.      |......|..||. |...:||.              .||...||:
  Rat   292 ASLLENMTVN------GLVLSVILPKELK-NISLIFEKIRKSGERKSQCVGWHSLESRWDRRACK 349

  Fly   178 -VELSKRE---YCVQHLSFKDDSIRIAPHF--CPLSSEHSRTWKTVAIVISLICIILTISVYLYV 236
             ::.:.|:   .|..:..|...||.::|:.  .|:.:..:.....::|...:||:.:...|:..|
  Rat   350 MIQENSRQAICRCQPNKFFTSFSILMSPNTVESPVLTYITYIGLGISICSLIICLAIEALVWSQV 414

  Fly   237 EKLRNLHGKCFICYLASLFLGYF---FLVLNVWKYSSGF----------CVTAGFLGYFSVIAAF 288
            .|..       |.||..|.:...   .|:.:||...:.|          ||||.|..:|..::.|
  Rat   415 TKTE-------ISYLRHLCIANIAVTLLMADVWFIVASFLSGPIVHHNGCVTATFFVHFFYLSVF 472

  Fly   289 FWLSVISLTLWNSFSGNSSWLNRF--LPQNRFLSYNLY--AWGMALLLTAITYIADQVVKNEKLR 349
            ||:...:|.:....      |..|  ||::..:: :|:  .:|..|::..||....:..|. .||
  Rat   473 FWMLAKALLILYGI------LIVFHTLPKSCLVA-SLFTVGYGCPLVIAVITLAVTEPGKG-YLR 529

  Fly   350 PRVGVGKNCWIYTGDMT-VMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEA--QNFTQQQKTTN 411
            |..     ||: ..||| .::.|..|.|.|:|.|:....|.   |:|.::.|  .:..|:.:...
  Rat   530 PEA-----CWL-NWDMTKALLAFVVPALAIVVVNLITVTLV---IIKTQRAAVGSSMFQEVRAIV 585

  Fly   412 RLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQGTVIF-LLFVLRP 475
            |:..:      ...|..::||:|...|.:.:...:.|:               .:|| ||..|:.
  Rat   586 RICKN------IAILTPLLGLTWGFGIATVVAGHSLAF---------------HIIFSLLNALQV 629

  Fly   476 STLKLLKERIKGGRDEAG 493
            |...:::...:|...|.|
  Rat   630 SPDAMIESEWRGCAVECG 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	36/216 (17%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	58/239 (24%)
Adgrf2	XP_017452241.2	GPS	330..377	CDD:413374	9/46 (20%)
		7tm_GPCRs	382..628	CDD:421689	65/290 (22%)
		TM helix 1	384..409	CDD:410628	3/24 (13%)
		TM helix 2	424..446	CDD:410628	4/21 (19%)
		TM helix 3	458..485	CDD:410628	9/26 (35%)
		TM helix 4	499..519	CDD:410628	5/20 (25%)
		TM helix 5	539..568	CDD:410628	10/31 (32%)
		TM helix 6	584..610	CDD:410628	6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910