DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgrg3

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_038954076.1	Gene:	Adgrg3 / 291854	RGDID:	1305674	Length:	574	Species:	Rattus norvegicus

Alignment Length:	351	Identity:	73/351 - (20%)
Similarity:	126/351 - (35%)	Gaps:	110/351 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WDKVELSK-----REYC-VQHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAIVISLICII-LTISV 232
            ||....|.     |..| ..||:|  .::.:.|   .|....:||...::...|.:.:| |..::
  Rat   255 WDSHGCSTEPGDGRTVCRCDHLTF--FALLLRP---TLDQATARTLTRISQAGSAVSMIFLAFTM 314

  Fly   233 YLYV-----------EKLRNLHGKCFICYLASLFLGYFFLVLNVWKYSSG---FC-VTAGFLGYF 282
            .|||           |....:|    :....||||.....::||...|.|   .| |.|....||
  Rat   315 VLYVAFRFSLQRFKSEDAPKIH----MALSTSLFLLNLTFLINVGSGSQGPPASCWVRAAIFHYF 375

  Fly   283 SVIAAFFW-------LSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIAD 340
             ::..|.|       |.::.:.::|::.|           :.||..:|..||:.:|:.
  Rat   376 -LLCVFTWMGLEAFHLYLLVIKVFNTYFG-----------HYFLKLSLLGWGLPVLIV------- 421

  Fly   341 QVVKNEKLRPRVGVGKN-------------------CWIYTGDMTVMIYFYGPMLLIIVFNITMF 386
                       :|||.:                   || :..:..:....:|..|:..:|...:.
  Rat   422 -----------IGVGSSNSYGVYTIRDQENRTSLELCW-FQKEPALYATVHGYFLVTFLFGAVVL 474

  Fly   387 VLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTY---ALFLRLFIIMGLSWSLEIISFL-LSKNQ 447
            .:.|::|         ||....|..:  ...||:   ...|.|..::|::|.|.:::.| ||
  Rat   475 AMVAWKI---------FTLPSVTAGK--GQGQTWKSVLTVLGLSSLVGMTWGLAVLTPLGLS--- 525

  Fly   448 AWAKAFMVADYFNWSQGTVIFLLFVL 473
                ...:....|..||..||..|::
  Rat   526 ----TVYIFTLLNSLQGLFIFCWFII 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	9/34 (26%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	51/264 (19%)
Adgrg3	XP_038954076.1	GPS	244..282	CDD:396408	8/28 (29%)
		7tm_GPCRs	292..551	CDD:421689	63/309 (20%)
		TM helix 1	294..319	CDD:410628	6/24 (25%)
		TM helix 2	333..355	CDD:410628	6/25 (24%)
		TM helix 3	366..393	CDD:410628	7/27 (26%)
		TM helix 4	406..426	CDD:410628	8/37 (22%)
		TM helix 5	454..481	CDD:410628	4/26 (15%)
		TM helix 6	495..522	CDD:410628	7/26 (27%)
		TM helix 7	524..549	CDD:410628	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810