DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgre5

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_036055.2	Gene:	Adgre5 / 26364	MGIID:	1347095	Length:	818	Species:	Mus musculus

Alignment Length:	283	Identity:	64/283 - (22%)
Similarity:	120/283 - (42%)	Gaps:	52/283 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 VAIVISLICIILTISVYLYVEKLRN----LHGKCFICYLASLFLGYFFLVLNVWKYSSGF---CV 274
            |.:::||||::|.|..:|.|:.:::    :|....||    ||||....::.|.......   |.
Mouse   535 VGLLLSLICLLLCILTFLLVKPIQSSRTMVHLHLCIC----LFLGSIIFLVGVENEGGEVGLRCR 595

  Fly   275 TAGFLGYFSVIAAFFWLSVISLTLW----NSFSGN--SSWLNRFLPQNRFLSYNLYAWGMALLLT 333
            ....:.:|..:|||.|:::..:.|:    ..|.|.  |:|      |...:.|     |:.||:.
Mouse   596 LVAVMLHFCFLAAFCWMALEGVELYFLVVRVFQGQGLSTW------QRCLIGY-----GVPLLIV 649

  Fly   334 AITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKK 398
            ||:.   .|||.:    ..|....||:.......:..|.||:..||..|..:||:|.:::.|
Mouse   650 AISM---AVVKMD----GYGHATYCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVITVWKLTK--- 704

  Fly   399 EAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYFNWSQ 463
               .|::......:|...:......:...:::|.:|...:  ||.:.:..|..  .:....|..|
Mouse   705 ---KFSEINPNMKKLRKARVLTITSIAQLLVLGCTWGFGL--FLFNPHSTWLS--YIFTLLNCLQ 762

  Fly   464 GTVIFLLFVLRPSTLKLLKERIK 486
            |..::::       |.||.::::
Mouse   763 GLFLYVM-------LCLLNKKVR 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	55/231 (24%)
Adgre5	NP_036055.2	EGF_CA	69..118	CDD:284955
		EGF_CA	165..212	CDD:284955
		EGF_CA	214..248	CDD:284955
		GPS	480..518	CDD:280071
		7tm_2	526..766	CDD:278432	61/262 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810