Protein Alignment mthl3 and mthl12

DIOPT Version :10

• Sequence 1: NP_663308.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 170/505 - (33%)
• Similarity: 274/505 - (54%)
• Gaps: 55/505 - (10%)

  Fly     9 TAFLLLLLQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKV 73
            |..::.:.:||:|:||.|.:.:|::||...|. |.:|:||...|||:||.|:|||.|.|.||...
  Fly    10 TLIIVTIAKNSSAKIPHCKYDETINISHFKRL-NDAYIYEHFEIPANLTGEFDYKELMDGSKVPT 73

  Fly    74 A-SHVRGCACHLRPCIRFCCPQYQKMQKSKCYG-----------DMSEDELNKHDPFVNVTLSDG 126
            . .::|||.|.:|||||.||.:...:...:|..           |::..::...||    ||::.
  Fly    74 EFPNLRGCICKVRPCIRICCARKNILSNGECSDGVKNEIKLTMLDLTMQDILLTDP----TLAEL 134

  Fly   127 SVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLS 191
            :::.::...:|::..:..:| |..:..|..:    |:|:.::||:|.|.....||..:||:....
  Fly   135 NMIPQYNSTELLILREQFQP-CDEIVSLKRD----EYTILKDGSILLHTSAEILSNDQYCLYPEI 194

  Fly   192 FKD--DSIRIAPHFCPLSSEHSRTWKTVA--IVISLICIILTISVYLYVEKLRNLHGKCFICYLA 252
            :.|  ::|||....|     :......:|  .|||::..|||::|||.|||||||.|||.||.|.
  Fly   195 YSDFPETIRIINRRC-----YRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLF 254

  Fly   253 SLFLGYFFLVLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNR 317
            |:|:.||...::.::.....|..||::.||..::::.|.||:|..||..|:.    |||..||.|
  Fly   255 SMFMEYFIWTMDYFRLLQSICSAAGYMKYFFSMSSYLWFSVVSFHLWELFTS----LNRHEPQYR 315

  Fly   318 FLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWI----YTG----DMTVMIYFYG- 373
            ||.||.:.|..|.:.|.:.:..:|:.:|:.       ||:.|:    |.|    |.....:||.
  Fly   316 FLIYNTFVWCTAAIPTVVIFSMNQMWENDP-------GKSEWLPLVGYFGCSVKDWNSSSWFYSH 373

  Fly   374 -PMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQ-QQKTTNRLNSDKQTYALFLRLFIIMGLSWSL 436
             |::::..||:.||||||..|.||||..::|.| .::.|..|..:.|||..|:|||:|||.||.|
  Fly   374 IPIVILNSFNVIMFVLTAIYIWKVKKGVKSFAQHDERNTTCLEFNVQTYIQFVRLFLIMGASWLL 438

  Fly   437 EIISFLLSKNQAWAKAFM--VADYFNWSQGTVIFLLFVLRPSTLKLLKER 484
            :.::.|...:.......:  :..|.|.:.|.:||:|.:|:.||.|::.||
  Fly   439 DQLTRLAEDSHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_663308.1	Methuselah_N	26..204	CDD:429053	57/191 (30%)
		7tmB3_Methuselah-like	208..486	CDD:410632	106/292 (36%)
		TM helix 1	210..235	CDD:410632	9/26 (35%)
		TM helix 2	244..266	CDD:410632	10/21 (48%)
		TM helix 3	274..301	CDD:410632	10/26 (38%)
		TM helix 4	318..338	CDD:410632	7/19 (37%)
		TM helix 5	364..393	CDD:410632	12/30 (40%)
		TM helix 6	415..442	CDD:410632	13/26 (50%)
		TM helix 7	450..475	CDD:410632	7/26 (27%)
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:429053	57/191 (30%)
		7tmB3_Methuselah-like	220..488	CDD:410632	103/278 (37%)
		TM helix 2	246..268	CDD:410632	10/21 (48%)
		TM helix 3	276..303	CDD:410632	10/26 (38%)
		TM helix 4	316..336	CDD:410632	7/19 (37%)
		TM helix 5	364..394	CDD:410632	11/29 (38%)
		TM helix 6	410..444	CDD:410632	15/33 (45%)
		TM helix 7	449..479	CDD:410632	7/29 (24%)