Protein Alignment mthl3 and mthl13

DIOPT Version :10

• Sequence 1: NP_663308.1
• Gene: mthl3 / 36961
• FlyBaseID: FBgn0028956
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_788325.2
• Gene: mthl13 / 246395
• FlyBaseID: FBgn0050018
• Length: 440
• Species: Drosophila melanogaster
• Alignment Length: 498
• Identity: 132/498 - (26%)
• Similarity: 222/498 - (44%)
• Gaps: 85/498 - (17%)

  Fly     4 VIGSFTAFLLLLLQNSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADD 68
            ::|:|...:||..|..|.:                  ||              ..|.|..:.:||
  Fly     5 LLGTFLVLILLQFQAVNTD------------------SN--------------KTEEDSCVKSDD 37

  Fly    69 SKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHF 133
            .......       .|..||..|||:...|....|   ..::.|.:....:|:.|.|.|....:|
  Fly    38 DNSNDED-------DLWHCIPICCPRKNMMANGGC---SFKEHLFRTKLDLNIRLDDNSTEALYF 92

  Fly   134 -KEDLIVQSDLAKPGCPRMYFLNHELPG---NEFTLFENGSLLRHWDKVELSKREYC-VQHLSFK 193
             .:.|::.|          ::...|:.|   :|:||::||::..|.|:...:|.||| ..|..:.
  Fly    93 NNQTLLITS----------FWDIDEMMGLRRDEYTLYKNGTIYIHSDQSIQTKEEYCFYPHQIYS 147

  Fly   194 D--DSIRIAPH-FCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLF 255
            |  ::|.|..| |..:.|..:....:.    |:||.|:...:||:|::|||..|||.:..:..||
  Fly   148 DFPETIWIISHKFSSIESPGAFELASG----SIICYIIIFGIYLFVKELRNDFGKCVMSCVFCLF 208

  Fly   256 LGYFFLVLNVWKYSSGFCVTAGFLGYFSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLS 320
            |.|...:::..:....||...|::.:|...|...|.|:||..:|...:...|..||    ::|:.
  Fly   209 LDYLIWLMDELRLLDDFCSLTGYIMFFFDFANSVWFSIISYCIWKKITSVVSQENR----DQFVF 269

  Fly   321 YNLYAWGMALLLTAITYIADQVVKNEKLR-----PRVGVGKNCWIYTGDMTVMIYFYGPMLLIIV 380
            |:.:|:|::.:...|....:|..: |.||     |.||..: |.:.....:..:|::.|..::..
  Fly   270 YSTFAYGISAIPLGIIISINQFWE-EDLRKWNWLPLVGFSR-CSVDDCKRSSWVYYFVPYAIMCA 332

  Fly   381 FNITMFVLTAFRIMKVKKEAQNFTQQQK------TTNRLNSDKQTYALFLRLFIIMGLSWSLEII 439
            .||.|||||...|||.|:...|.|::..      |.|.||.  :.|.||||:..|||::|.| ||
  Fly   333 INIIMFVLTIKHIMKTKRNLHNLTKRPDRNETCVTVNFLNF--ELYLLFLRISGIMGVAWIL-II 394

  Fly   440 SFLLSKNQAWAKAF-MVADYFNWSQGTVIFLLFVLRPSTLKLL 481
            ..|:..|..:...| ::....::..|.::|:|.:.:.||.:||
  Fly   395 FLLIEVNSTFWDIFGIIIQQIHYGFGIILFVLLIFKRSTHQLL 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_663308.1	Methuselah_N	26..204	CDD:429053	40/185 (22%)
		7tmB3_Methuselah-like	208..486	CDD:410632	85/286 (30%)
		TM helix 1	210..235	CDD:410632	5/24 (21%)
		TM helix 2	244..266	CDD:410632	7/21 (33%)
		TM helix 3	274..301	CDD:410632	8/26 (31%)
		TM helix 4	318..338	CDD:410632	5/19 (26%)
		TM helix 5	364..393	CDD:410632	9/28 (32%)
		TM helix 6	415..442	CDD:410632	12/26 (46%)
		TM helix 7	450..475	CDD:410632	4/25 (16%)
mthl13	NP_788325.2	Mth_Ecto	<49..158	CDD:448329	32/121 (26%)
		7tm_GPCRs	186..440	CDD:475119	80/261 (31%)
		TM helix 2	197..218	CDD:410628	7/20 (35%)
		TM helix 3	227..249	CDD:410628	6/21 (29%)
		TM helix 4	269..285	CDD:410628	3/15 (20%)
		TM helix 5	316..339	CDD:410628	5/22 (23%)
		TM helix 6	376..397	CDD:410628	12/21 (57%)
		TM helix 7	402..431	CDD:410628	4/28 (14%)