DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl3 and Adgrg4

DIOPT Version :9

Sequence 1:	NP_001286526.1	Gene:	mthl3 / 36961	FlyBaseID:	FBgn0028956	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001349814.1	Gene:	Adgrg4 / 236798	MGIID:	2685213	Length:	3025	Species:	Mus musculus

Alignment Length:	414	Identity:	92/414 - (22%)
Similarity:	157/414 - (37%)	Gaps:	121/414 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWD- 176
            |..||.:        ::.:|.:.|                 .|::.....|..|:..:.|..|:
Mouse  2564 NLADPVI--------IILKHIQGD-----------------WNYDQVYCAFWDFDTNNGLGGWNP 2603

  Fly   177 ---KVELSKREYCV---QHLSFKDDSIRIAPHFCPLSSEHSRTWKTVAIVISLICIILTIS---- 231
               |::.|...|.:   .||:          ||..| .:.||:  ||..|...|.:|:|.:
Mouse  2604 SGCKLKESNINYTICQCNHLT----------HFGVL-MDLSRS--TVDAVNERILVIITYTGCGI 2655

  Fly   232 ----------VYLYVEKLRNLHGKCFICYL--ASLFLGYFFLVLNVWKYS---SGFCVTAGFLGY 281
                      .|:...|||..:....:..|  |.|.|...||| |.|..|   .|.|:||....:
Mouse  2656 SSIFLGIAMVTYIAFHKLRKDYPSKILINLCTALLMLNLAFLV-NSWLTSFQKVGLCITAAVALH 2719

  Fly   282 FSVIAAFFWLSVISLTLWNSFSGNSSWLNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNE 346
            :.::.:..|:.:.::.::.:.   ....|.::| |..|.:.|..||:..:..||      ::...
Mouse  2720 YFLLVSLTWMGLEAVHMYFAL---VKVFNTYIP-NYILKFCLAGWGIPAITVAI------ILSVR 2774

  Fly   347 K-----LRPRVGVGKNCWI---YTGDMTVMIYFYGPMLLIIVFNITMFVLTAFRIMKVKKEAQNF 403
            |     |.|....   |||   :...::|:.||    .||.:.|::||.....::..||
Mouse  2775 KDLYGTLSPTTPF---CWIKDDHIFYISVVAYF----CLIFLMNLSMFCTVLVQLTSVK------ 2826

  Fly   404 TQQQKTTNR--LNSDKQTYALFLRLFIIMGLSWSLEIISFLLSKNQAWAKAFMVADYF----NWS 462
            :|.|||..:  ||..|.|    :.|..::||:|.....        ||....:...|.    |..
Mouse  2827 SQSQKTRKKMILNDLKGT----ISLTFLLGLTWGFAFF--------AWGPVRIFFLYLFAICNTL 2879

  Fly   463 QGTVIFLLFVLRPSTLKLLKERIK 486
            ||.:||:.:.       ::||.::
Mouse  2880 QGFLIFVFYC-------VMKESVR 2896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl3	NP_001286526.1	Methuselah_N	26..204	CDD:284145	16/97 (16%)
mthl3	NP_001286526.1	7tm_4	216..436	CDD:304433	62/248 (25%)
Adgrg4	NP_001349814.1	LamG	<54..162	CDD:328935
		DnaJ	<276..746	CDD:333066
		GPS	2587..2629	CDD:307782	11/51 (22%)
		7tmB2_GPR112	2642..2903	CDD:320663	69/298 (23%)
		TM helix 1	2644..2669	CDD:320663	4/24 (17%)
		TM helix 2	2679..2701	CDD:320663	8/22 (36%)
		TM helix 3	2712..2739	CDD:320663	3/26 (12%)
		TM helix 4	2754..2770	CDD:320663	5/21 (24%)
		TM helix 5	2793..2816	CDD:320663	7/26 (27%)
		TM helix 6	2838..2863	CDD:320663	9/36 (25%)
		TM helix 7	2867..2892	CDD:320663	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910