DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl3 and ADGRL2

DIOPT Version :9

Sequence 1:NP_001286526.1 Gene:mthl3 / 36961 FlyBaseID:FBgn0028956 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_001352934.1 Gene:ADGRL2 / 23266 HGNCID:18582 Length:1469 Species:Homo sapiens


Alignment Length:356 Identity:80/356 - (22%)
Similarity:143/356 - (40%) Gaps:78/356 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 PRMYFLNHELPGNEFTL------FENGSLLRHWDK-----VELSK-REYCV-QHLSFKDDSIRIA 200
            |.::.|.|..|.|.|..      :...:::.:|..     |:.:| |..|. .||:         
Human   774 PVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLT--------- 829

  Fly   201 PHFCPLSSEHSRTWKT------------VAIVISLICIILTISVYLYVEKLRN----LHGKCFIC 249
             :|..|.:.....:|.            |.|||||:|:.:.|..:.:...|::    :|....| 
Human   830 -NFAILMAHREIAYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCI- 892

  Fly   250 YLASLFLGYFFLVLNV--WKYSSGFCVTAGFLGYFSVIAAFFWLSV----ISLTLWNSFSGNSSW 308
               :||:..|..::.:  .||:....:.||.|.:| .:|||.|:.:    :.|.|...|....|.
Human   893 ---NLFIAEFIFLIGIDKTKYAIACPIFAGLLHFF-FLAAFAWMCLEGVQLYLMLVEVFESEYSR 953

  Fly   309 LNRFLPQNRFLSYNLYAWGMALLLTAITYIADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYG 373
            ...:     :::..|:...:..:..||.|            ...|..|.||::. |...:..|.|
Human   954 KKYY-----YVAGYLFPATVVGVSAAIDY------------KSYGTEKACWLHV-DNYFIWSFIG 1000

  Fly   374 PMLLIIVFNITMFVLTAFRIMKVKKEAQNFTQQQKTTNRLNSDKQTYALFLRLFIIMGLSWSLEI 438
            |:..||:.||...|:|..:::|      :....:..::||.:.|........|..::||:||..:
Human  1001 PVTFIILLNIIFLVITLCKMVK------HSNTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGL 1059

  Fly   439 ISFLLSKNQAWAKAFMVADYFNWSQGTVIFL 469
            : |:..:....|..|.:   ||..||..||:
Human  1060 L-FINEETIVMAYLFTI---FNAFQGVFIFI 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl3NP_001286526.1 Methuselah_N 26..204 CDD:284145 13/67 (19%)
7tm_4 216..436 CDD:304433 54/241 (22%)
ADGRL2NP_001352934.1 Gal_Lectin 49..129 CDD:307994
OLF 142..398 CDD:321983
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..460
HormR 469..533 CDD:214468
GAIN 542..764 CDD:318649
GPS 788..840 CDD:197639 10/61 (16%)
7tmB2_Latrophilin-2 848..1105 CDD:320672 64/272 (24%)
TM helix 1 850..875 CDD:320672 8/24 (33%)
TM helix 2 884..906 CDD:320672 5/25 (20%)
TM helix 3 915..942 CDD:320672 8/27 (30%)
TM helix 4 954..974 CDD:320672 1/24 (4%)
TM helix 5 991..1020 CDD:320672 10/28 (36%)
TM helix 6 1036..1063 CDD:320672 7/27 (26%)
TM helix 7 1067..1092 CDD:320672 8/23 (35%)
Latrophilin 1104..1469 CDD:308136
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1368..1410
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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